2-(5-chloropyridin-2-yl)acetonitrile

Base Information

• Chemical Name: 2-(5-chloropyridin-2-yl)acetonitrile
• CAS No.: 185315-51-9
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.583
• Hs Code.: 2933399090
• Mol file: 185315-51-9.mol

Synonyms:2-(5-chloropyridin-2-yl)acetonitrile;(5-Chloro-pyridin-2-yl)-acetonitrile;5-chloro-2-Pyridineacetonitrile

Chemical Property of 2-(5-chloropyridin-2-yl)acetonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 1.80108
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(5-Chloropyridin-2-yl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(5-chloropyridin-2-yl)acetonitrile

There total 3 articles about 2-(5-chloropyridin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

potassium cyanide + 5-chloro-pyridin-2-ylmethyl chloride (10177-24-9) → (5-chloropyridin-2-yl)acetonitrile (185315-51-9)

Guidance literature:

In ethanol; at 100 ℃; for 1h;

Reference yield:

tert-butyl 2-(5-chloropyridin-2-yl)-2-cyanoacetate → (5-chloropyridin-2-yl)acetonitrile (185315-51-9)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1016/j.bmcl.2004.05.056

Reference yield:

2,5 dichloropyridine (16110-09-1) → (5-chloropyridin-2-yl)acetonitrile (185315-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1.5 h / 20 °C / Inert atmosphere

1.2: 3 h / 120 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / acetonitrile / 1 h / Reflux

With sodium hydride; toluene-4-sulfonic acid; In dimethyl sulfoxide; acetonitrile; mineral oil;

upstream raw materials:

5-chloro-pyridin-2-ylmethyl chloride

2,5 dichloropyridine

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