tert-Butyl (5-iodothiazol-4-yl)carbaMate

Base Information

• Chemical Name: tert-Butyl (5-iodothiazol-4-yl)carbaMate
• CAS No.: 1258934-68-7
• Molecular Formula: C8H11IN2O2S
• Molecular Weight: 326.158
• Mol file: 1258934-68-7.mol

Synonyms:tert-Butyl (5-iodothiazol-4-yl)carbaMate;Carbamic acid, N-(5-iodo-4-thiazolyl)-, 1,1-dimethylethyl ester

Chemical Property of tert-Butyl (5-iodothiazol-4-yl)carbaMate

Chemical Property:

• PSA: 79.46000
• LogP: 3.16770

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(5-iodothiazol-4-yl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl (5-iodothiazol-4-yl)carbaMate

There total 1 articles about tert-Butyl (5-iodothiazol-4-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

thiazol-4-ylaminocarboxylic acid tert-butyl ester (1235406-42-4) → tert-butyl N-(5-iodo-1,3-thiazol-4-yl)carbamate (1258934-68-7)

Guidance literature:

With N-iodo-succinimide; In 1,2-dichloro-ethane; at 83 ℃; for 2h;

Reference yield: 92.0%

tert-butyl N-(5-iodo-1,3-thiazol-4-yl)carbamate (1258934-68-7) + C15H13N (864754-01-8) → tert-butyl N-(5-{3-[(benzylamino)phenyl]ethynyl}-1,3-thiazol-4-yl)carbamate (1258934-78-9)

Guidance literature:

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1055/s-0030-1258159

Reference yield: 92.0%

propargyl benzene (10147-11-2) + tert-butyl N-(5-iodo-1,3-thiazol-4-yl)carbamate (1258934-68-7) → tert-butyl N-[5-(3-phenylprop-1-ynyl)-1,3-thiazol-4-yl]carbamate (1258934-97-2)

Guidance literature:

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; at 50 ℃; for 6h; Inert atmosphere;

DOI:10.1055/s-0030-1258159

upstream raw materials:

thiazol-4-ylaminocarboxylic acid tert-butyl ester

Downstream raw materials:

tert-butyl N-{5-[2-(4-fluorophenyl)ethynyl]-1,3-thiazol-4-yl}carbamate

thiazol-4-ylaminocarboxylic acid tert-butyl ester

C₁₁H₇FN₂S

tert-butyl N-(5-{3-[(benzylamino)phenyl]ethynyl}-1,3-thiazol-4-yl)carbamate

Refernces

• 1、 -. "INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES". Page/Page column 221-222. . Retrieved 2019/04/16.
• 2、 -. "THIAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER". Page/Page column 22. . Retrieved 2012/10/08.