5-Hydroxy Bromantane

Base Information

• Chemical Name: 5-Hydroxy Bromantane
• CAS No.: 560070-28-2
• Molecular Formula: C₁₆H₂₀BrNO
• Molecular Weight: 322.245
• DSSTox Substance ID: DTXSID50476312
• Mol file: 560070-28-2.mol

Synonyms:5-Hydroxy Bromantane;560070-28-2;4-(4-bromoanilino)adamantan-1-ol;4-[(4-Bromophenyl)amino]tricyclo[3.3.1.13,7]decan-1-ol;DTXSID50476312;4-((4-Bromophenyl)amino)adamantan-1-ol;FT-0669425

Chemical Property of 5-Hydroxy Bromantane

Chemical Property:

• PSA: 32.26000
• LogP: 3.87360
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Ethyl Acetate
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 321.07283
• Heavy Atom Count: 19
• Complexity: 337

Purity/Quality:

5-HydroxyBromantane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C2CC3CC(C2)(CC1C3NC4=CC=C(C=C4)Br)O
• Uses: 5-Hydroxy Bromantane is a metabolite of Bromantane (B678450). 5-Hydroxy bromantane is a metabolite of Bromantane (B678450), an immunostimulant with a psychostimulating effect.

Technology Process of 5-Hydroxy Bromantane

There total 6 articles about 5-Hydroxy Bromantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxy-2-adamantanone → trans-N-(5-hydroxyadamant-2-yl)-p-bromoaniline (560070-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 11 h / 150 - 160 °C

2: aq. HCl / formic acid / Heating

With hydrogenchloride; In formic acid; 1: Leuckart reaction;

DOI:10.1023/A:1020820405232

Reference yield:

5-hydroxy-2-adamantanone → cis-N-(5-hydroxyadamant-2-yl)-p-bromoaniline (560070-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 11 h / 150 - 160 °C

2: aq. HCl / formic acid / Heating

With hydrogenchloride; In formic acid; 1: Leuckart reaction;

DOI:10.1023/A:1020820405232

Reference yield:

4-bromo-aniline (106-40-1) → cis-N-(5-hydroxyadamant-2-yl)-p-bromoaniline (560070-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 11 h / 150 - 160 °C

2: aq. HCl / formic acid / Heating

With hydrogenchloride; In formic acid; 1: Leuckart reaction;

DOI:10.1023/A:1020820405232

upstream raw materials:

4-bromo-aniline