Azido-PEG2-CH2CO2H

Base Information

• Chemical Name: Azido-PEG2-CH2CO2H
• CAS No.: 882518-90-3
• Molecular Formula: C6H11N3O4
• Molecular Weight: 189.171
• Mol file: 882518-90-3.mol

Synonyms:Azido-PEG2-CH2CO2H

Chemical Property of Azido-PEG2-CH2CO2H

Chemical Property:

• PSA: 105.51000
• LogP: -0.13274
• Solubility.: Soluble in Water

Purity/Quality:

98%,99%, ^*data from raw suppliers

Azido-PEG2-CH2CO2H ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG2-CH2CO2H is a water soluble click chemistry reagent containing an azide group with a terminal carboxylic acid. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of Azido-PEG2-CH2CO2H

There total 2 articles about Azido-PEG2-CH2CO2H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

propargyl chloroformate (35718-08-2) + tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate (169396-89-8) → N-(2-(2-(2-azidoethoxy)ethoxy))acetic acid (882518-90-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; for 2h; Inert atmosphere;

DOI:10.1016/j.bioorg.2014.03.001

Reference yield: 91.0%

2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7) → N-(2-(2-(2-azidoethoxy)ethoxy))acetic acid (882518-90-3)

Guidance literature:

With Jones reagent; In acetone; at 4 - 20 ℃;

DOI:10.1039/b807263a

Reference yield: 100.0%

N-(2-(2-(2-azidoethoxy)ethoxy))acetic acid (882518-90-3) → [2-(N-2-amino ethoxy)ethoxy] acetic acid (134978-97-5,139729-28-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 4 - 20 ℃;

DOI:10.1039/b807263a

upstream raw materials:

2-[2-(2-azidoethoxy)ethoxy]ethanol

propargyl chloroformate

tert-butyl N-(2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}ethyl)glycinate

Downstream raw materials:

succinimidyl 8-azido-3,6-dioxaoctanoate

[2-(N-2-amino ethoxy)ethoxy] acetic acid

C₁₉H₂₈N₄O₇

Refernces

• 1、 -. "TARGETED BIFUNCTIONAL DEGRADERS". Page/Page column 189. . Retrieved 2021/04/17.
• 2、 Russo, Laura,Landi, Elena,Tampieri, Anna,Natalello, Antonino,Doglia, Silvia M.,Gabrielli, Luca,Cipolla, Laura,Nicotra, Francesco. "Sugar-decorated hydroxyapatite: An inorganic material bioactivated with carbohydrates". scheme or table. p. 1564 - 1568. Retrieved 2011/08/08.