2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL

Base Information

• Chemical Name: 2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL
• CAS No.: 86520-52-7
• Molecular Formula: C6H13N3O3
• Molecular Weight: 175.188
• Hs Code.: 2929909090
• European Community (EC) Number: 694-430-1
• DSSTox Substance ID: DTXSID50451649
• Nikkaji Number: J924.882J
• Mol file: 86520-52-7.mol

Synonyms:2-[2-(2-Azidoethoxy)ethoxy]ethanol;

Chemical Property of 2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL

Chemical Property:

• Appearance/Colour: Yellowish liquid
• Flash Point: -33℃
• PSA: 88.44000
• LogP: -0.22504
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 175.09569129
• Heavy Atom Count: 12
• Complexity: 136

Purity/Quality:

97% ^*data from raw suppliers

2-[2-(2-Azidoethoxy)ethoxy]ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-38
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCO)N=[N+]=[N-]
• Description: Azido-PEG3-alcohol is a click chemistry PEG linker containing an azide group and a terminal hydroxyl group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Technology Process of 2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL

There total 14 articles about 2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

8-tosyloxy-3,6-dioxaoctanol (77544-68-4) → 2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ica.2010.07.067

Reference yield: 100.0%

2-[2-(chloroethoxy)ethoxy]ethanol (5197-62-6) → 2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 0 - 100 ℃;

Reference yield: 100.0%

2-<2-<2-<(Methanesulfonyl)oxy>ethoxy>ethoxy>ethanol (139115-89-2) → 2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

upstream raw materials:

8-tosyloxy-3,6-dioxaoctanol

2-<2-<2-<(Methanesulfonyl)oxy>ethoxy>ethoxy>ethanol

2-[2-(chloroethoxy)ethoxy]ethanol

2-<2-(2-methanesulfoxyethoxy)ethoxy>ethyl acetate

Downstream raw materials:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

2-[2-(2-Azidoethoxy)ethoxy]ethyl 3,4,6-tri-O-acetyl-2-N-acetamido-2-deoxy-β-D-glucopyranoside

(2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(2-(2-(2-azidoethoxy)ethoxy)ethoxy) tetrahydro-2H-pyran-3,4,5-triyl triacetate

(2S)-(+)-methyl 12-azido-2-(N-benzyloxycarbonylamino)-4,7,10-trioxadodecanoate