Technology Process of 5-ForMyl-6-Methoxy-2,4-diMethylnicotinonitrile
There total 4 articles about 5-ForMyl-6-Methoxy-2,4-diMethylnicotinonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
dichloromethane; toluene;
at 0 - 20 ℃;
for 6h;
DOI:10.1021/jo026621n
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 67 percent / silver carbonate / benzene / 48 h
2: 92 percent / H2SO4; NBS / trifluoroacetic acid / 24 h / 20 °C
3: 61 percent / dimethylformamide / 10 h / Heating
4: DIBAL-H / toluene; CH2Cl2 / 6 h / 0 - 20 °C
With
N-Bromosuccinimide; sulfuric acid; diisobutylaluminium hydride; silver carbonate;
In
dichloromethane; N,N-dimethyl-formamide; toluene; trifluoroacetic acid; benzene;
DOI:10.1021/jo026621n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / H2SO4; NBS / trifluoroacetic acid / 24 h / 20 °C
2: 61 percent / dimethylformamide / 10 h / Heating
3: DIBAL-H / toluene; CH2Cl2 / 6 h / 0 - 20 °C
With
N-Bromosuccinimide; sulfuric acid; diisobutylaluminium hydride;
In
dichloromethane; N,N-dimethyl-formamide; toluene; trifluoroacetic acid;
DOI:10.1021/jo026621n
