65515-39-1 Usage
Description
2-Methoxy-4,6-dimethylnicotinonitrile, with the chemical formula C9H10N2O, is an organic nitrile derivative characterized by the presence of a methoxy group and two methyl groups attached to a nicotinonitrile ring. 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE is recognized for its unique chemical structure and properties, which render it a valuable building block in chemical synthesis and various industrial processes.
Uses
Used in Pharmaceutical Synthesis:
2-Methoxy-4,6-dimethylnicotinonitrile is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agricultural Chemical Production:
2-METHOXY-4,6-DIMETHYLNICOTINONITRILE also serves as an intermediate in the production of agricultural chemicals, playing a crucial role in the creation of pesticides and other agrochemicals that are essential for crop protection and increased agricultural yields.
Used in Fine Chemicals Manufacturing:
2-Methoxy-4,6-dimethylnicotinonitrile is employed in the manufacturing of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, fragrances, and flavors. Its presence in these products ensures quality and consistency.
Used in Research and Development:
Due to its potential applications and unique properties, 2-Methoxy-4,6-dimethylnicotinonitrile is a valuable compound in research settings. It is used to explore new chemical reactions, investigate its reactivity, and develop novel applications in various fields, thereby contributing to scientific progress and innovation.
Check Digit Verification of cas no
The CAS Registry Mumber 65515-39-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,5,1 and 5 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 65515-39:
(7*6)+(6*5)+(5*5)+(4*1)+(3*5)+(2*3)+(1*9)=131
131 % 10 = 1
So 65515-39-1 is a valid CAS Registry Number.
65515-39-1Relevant articles and documents
The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat
Kuntz, Kevin W.,Campbell, John E.,Keilhack, Heike,Pollock, Roy M.,Knutson, Sarah K.,Porter-Scott, Margaret,Richon, Victoria M.,Sneeringer, Chris J.,Wigle, Tim J.,Allain, Christina J.,Majer, Christina R.,Moyer, Mikel P.,Copeland, Robert A.,Chesworth, Richard
supporting information, p. 1556 - 1564 (2016/03/05)
Posttranslational methylation of histones plays a critical role in gene regulation. Misregulation of histone methylation can lead to oncogenic transformation. Enhancer of Zeste homologue 2 (EZH2) methylates histone 3 at lysine 27 (H3K27) and abnormal methylation of this site is found in many cancers. Tazemetostat, an EHZ2 inhibitor in clinical development, has shown activity in both preclinical models of cancer as well as in patients with lymphoma or INI1-deficient solid tumors. Herein we report the structure-activity relationships from identification of an initial hit in a high-throughput screen through selection of tazemetostat for clinical development. The importance of several methyl groups to the potency of the inhibitors is highlighted as well as the importance of balancing pharmacokinetic properties with potency.
Methyl orthocarboxylates as methylating agents of heterocycles
Janin, Yves L.,Huel, Christiane,Flad, Genevieve,Thirot, Sylvie
, p. 1763 - 1769 (2007/10/03)
Methylation reactions occurring between trimethyl orthocarboxylates or N,N-dimethylcarboxamide dimethyl acetals and various hydroxylated heterocycles, involving a lactam-lactim tautomeric equilibrium, were investigated as an alternative to classic methyla
An Unusual Photodimerisation of a Pyrone Analogue; X-Ray Crystal Structure of the Principal Product
Alcock, Nathaniel W.,Samuel, Christopher J.
, p. 603 - 604 (2007/10/02)
Irradiation of 4-dicyanomethylene-2,6-dimethyl-4H-pyran (1) in methanol leads to the dimers (2) and (3); the structure of (2) has been determined by X-ray crystallography.