65515-39-1

Basic information

• Product Name: 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE
• Synonyms: 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE;2-Methoxy-3-cyano-4,6-diMethylpyridine;3-Cyano-4,6-dimethyl-2-methoxypyridine, 2-Methoxy-4,6-dimethylpyridine-3-carbonitrile;3-Cyano-2-Methoxy-4,6-diMethylpyridine
• CAS NO: 65515-39-1
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• EINECS: 692-428-5
• Product Categories: Pyridines;cyanide
• Mol File: 65515-39-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 282-284℃
• Boiling Point: 294.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.32±0.18(Predicted)
• CAS DataBase Reference: 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE(65515-39-1)
• EPA Substance Registry System: 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE(65515-39-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 65515-39-1(Hazardous Substances Data)

Usage

General Description

2-Methoxy-4,6-dimethylnicotinonitrile is a chemical compound with the formula C9H10N2O. It is an organic nitrile derivative with a methoxy group and two methyl groups attached to a nicotinonitrile ring. 2-METHOXY-4,6-DIMETHYLNICOTINONITRILE is commonly used as an intermediate in the synthesis of various pharmaceuticals and agricultural chemicals. It is also utilized in the production of fine chemicals and research. 2-Methoxy-4,6-dimethylnicotinonitrile has a variety of potential applications due to its unique chemical structure and properties, making it a valuable building block in chemical synthesis and industrial processes.

Upstream product

• 124-41-4 sodium methylate 
• 3102-33-8 trans-3-penten-2-one 
• 109-77-3 malononitrile 
• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 
• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 
• 123-54-6 acetylacetone 

Downstream Products

• 26413-74-1 (2-methoxy-4,6-dimethyl-3-pyridyl)methanol 

Relevant articles and documents

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

Posttranslational methylation of histones plays a critical role in gene regulation. Misregulation of histone methylation can lead to oncogenic transformation. Enhancer of Zeste homologue 2 (EZH2) methylates histone 3 at lysine 27 (H3K27) and abnormal methylation of this site is found in many cancers. Tazemetostat, an EHZ2 inhibitor in clinical development, has shown activity in both preclinical models of cancer as well as in patients with lymphoma or INI1-deficient solid tumors. Herein we report the structure-activity relationships from identification of an initial hit in a high-throughput screen through selection of tazemetostat for clinical development. The importance of several methyl groups to the potency of the inhibitors is highlighted as well as the importance of balancing pharmacokinetic properties with potency.

Methyl orthocarboxylates as methylating agents of heterocycles

Methylation reactions occurring between trimethyl orthocarboxylates or N,N-dimethylcarboxamide dimethyl acetals and various hydroxylated heterocycles, involving a lactam-lactim tautomeric equilibrium, were investigated as an alternative to classic methyla

An Unusual Photodimerisation of a Pyrone Analogue; X-Ray Crystal Structure of the Principal Product

Irradiation of 4-dicyanomethylene-2,6-dimethyl-4H-pyran (1) in methanol leads to the dimers (2) and (3); the structure of (2) has been determined by X-ray crystallography.