(6aR,10aR)-1-[tert-butyl(dimethyl)silyl]oxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid

Base Information

Chemical Name:(6aR,10aR)-1-[tert-butyl(dimethyl)silyl]oxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid
CAS No.:138285-38-8
Molecular Formula:C27H42O4Si
Molecular Weight:458.714
Hs Code.:
DSSTox Substance ID:DTXSID90449444
Wikidata:Q82268909
Mol file:138285-38-8.mol

Synonyms:138285-38-8;(6aR,10aR)-1-[tert-butyl(dimethyl)silyl]oxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid;DTXSID90449444;1-O-[(tert-Butyl)dimethylsilyloxy]-9-carboxylate-| currency9-tetrahydro Cannabinol

Suppliers and Price of (6aR,10aR)-1-[tert-butyl(dimethyl)silyl]oxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
1-O-[(tert-Butyl)dimethylsilyloxy]-9-carboxylate-delta9-tetrahydro cannabinol
10 mg
$ 1638.00

Biosynth Carbosynth
1-O-[(tert-Butyl)dimethylsilyloxy]-9-carboxylate-delta9-tetrahydro cannabinol
5 mg
$ 900.90

Biosynth Carbosynth
1-O-[(tert-Butyl)dimethylsilyloxy]-9-carboxylate-delta9-tetrahydro cannabinol
2 mg
$ 495.50

Biosynth Carbosynth
1-O-[(tert-Butyl)dimethylsilyloxy]-9-carboxylate-delta9-tetrahydro cannabinol
1 mg
$ 272.60

Total 1 raw suppliers

Chemical Property of (6aR,10aR)-1-[tert-butyl(dimethyl)silyl]oxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid

Chemical Property:

PSA：55.76000
LogP:7.47890
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:458.28523635
Heavy Atom Count:32
Complexity:705

Purity/Quality:: 1-O-[(tert-Butyl)dimethylsilyloxy]-9-carboxylate-delta9-tetrahydro cannabinol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC1=CC2=C(C3C=C(CCC3C(O2)(C)C)C(=O)O)C(=C1)O[Si](C)(C)C(C)(C)C
Isomeric SMILES:CCCCCC1=CC2=C([C@@H]3C=C(CC[C@H]3C(O2)(C)C)C(=O)O)C(=C1)O[Si](C)(C)C(C)(C)C
Uses (6aR-trans)-1-[(tert-Butyl)diMethylsilyloxy is used in the preparation of a major Tetrahydrocannabinol (T293200) metabolite.

Technology Process of (6aR,10aR)-1-[tert-butyl(dimethyl)silyl]oxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid

There total 8 articles about (6aR,10aR)-1-[tert-butyl(dimethyl)silyl]oxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 136954-91-1,138285-36-6
(+/-)-11-oxo-Δ⁹-tetrahydrocannabiol tert-butyldimethylsilyl ether

: 138176-22-4,138285-38-8
(+/-)-11-nor-9-carboxy-Δ⁹-tetrahydrocannabinol tert-butyldimethylsilyl ether

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; for 2.5h; Ambient temperature;
DOI:10.1055/s-1991-26590

Reference yield:

: 138285-36-6
(-)-11-oxo-Δ⁹-tetrahydrocannabinol tert-butyldimethylsilyl ether

: 138285-38-8
(-)-11-nor-9-carboxy-Δ⁹-tetrahydrocannabinol tert-butyldimethylsilyl ether

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; Ambient temperature;
DOI:10.1055/s-1991-26590

Reference yield:

: 52663-85-1
(6aR,10aR)-1-Hydroxy-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromene-9-carbaldehyde

: 138285-38-8
(-)-11-nor-9-carboxy-Δ⁹-tetrahydrocannabinol tert-butyldimethylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / Ambient temperature

2: 2-methyl-2-butene, 80percent NaClO₂, NaH₂PO₄ / 2-methyl-propan-2-ol; H₂O / Ambient temperature

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1055/s-1991-26590