N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Base Information

• Chemical Name: N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine
• CAS No.: 862370-79-4
• Molecular Formula: C23H32N6O2
• Molecular Weight: 424.53918
• DSSTox Substance ID: DTXSID90464950
• Wikidata: Q82290532
• Mol file: 862370-79-4.mol

Synonyms:862370-79-4;N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine;2-N-[4-(diethylamino)butyl]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine;AGN-PC-008HZA;SCHEMBL6056003;DTXSID90464950;FT-0666733;N2-(4-(Diethylamino)butyl)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine

Chemical Property of N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

Chemical Property:

• PSA: 101.65000
• LogP: 3.82820
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 11
• Exact Mass: 424.25867428
• Heavy Atom Count: 31
• Complexity: 497

Purity/Quality:

N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)N
• Uses: Used in the preparation of naphthyridinamines and related ureas as a selective FGFR1 and FGFR3 inhibitor. N2-[4-(DiethylaMino)butyl]-6-(3,5-diMethoxyphenyl)-pyrido[2,3-d]pyriMidine-2,7-diaMine can bu used in the preparation of naphthyridinamines and related ureas as a selective FGFR1.

Technology Process of N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

There total 5 articles about N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-(3,5-dimethoxyphenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7-amine (862370-78-3) + 4-(diethylamino)butylamine (27431-62-5) → N2-[4-(diethylamino)butyl]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine (862370-79-4)

Guidance literature:

In 1,4-dioxane; at 50 ℃;

DOI:10.1021/jm0500931

Reference yield:

4-(diethylamino)butylamine (27431-62-5) + 6-(3,5-dimethoxy-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (192705-78-5) → N2-[4-(diethylamino)butyl]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine (862370-79-4)

Guidance literature:

With aminosulfonic acid; at 140 - 180 ℃;

Reference yield:

6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine (862370-77-2) → N2-[4-(diethylamino)butyl]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine (862370-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 18.30 g / 2-(phenylsulfonyl)-3-phenyloxaziridine / CHCl₃ / 24 h / 20 °C

2: 72 percent / dioxane / 50 °C

With N-(benzenesulfonyl)-3-phenyloxaziridine; In 1,4-dioxane; chloroform;

DOI:10.1021/jm0500931

upstream raw materials:

6-(3,5-dimethoxyphenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7-amine

4-(diethylamino)butylamine

6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde