6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine

Base Information

• Chemical Name: 6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine
• CAS No.: 862370-77-2
• Molecular Formula: C₁₆H₁₆N₄O₂S
• Molecular Weight: 328.395
• Mol file: 862370-77-2.mol

Synonyms:6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine

Chemical Property of 6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine

There total 6 articles about 6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde (770-31-0) + 3,5-dimethoxyphenylacetonitrile (13388-75-5) → 6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine (862370-77-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 5 - 20 ℃; for 23h; Inert atmosphere;

DOI:10.1039/b923882d

Reference yield:

3,5-dimethoxyphenylacetonitrile (13388-75-5) + sodium hydride (7646-69-7) → 6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine (862370-77-2)

Guidance literature:

3,5-dimethoxyphenylacetonitrile; With sodium hydride; In tetrahydrofuran; at 18 - 25 ℃; for 1.5h;

sodium hydride; In tetrahydrofuran; at 18 - 25 ℃; for 19h;

Reference yield:

(4-amino-2-(methylthio)pyrimidin-5-yl)methanol (588-36-3) → 6-(3,5-dimethoxyphenyl)-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-amine (862370-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / dichloromethane / 12 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C

2.2: 0 - 20 °C

With manganese(IV) oxide; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;

upstream raw materials:

4-amino-2-(methylthio)pyrimidine-5-carbaldehyde

3,5-dimethoxyphenylacetonitrile

sodium hydride

ethyl 4-amino-2-methylmercaptopyrimidine-5-carboxylate

Downstream raw materials:

C₂₁H₂₅N₅O₃S

N-(tert-butyl)-N'-[2-[[3-[[tert-butyl(dimethyl)silyl]oxy]propyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

6-(3,5-dimethoxyphenyl)-N²-[3-(4-methyl-1-piperazinyl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine