6-Chloro-2,4-dimethylnicotinic acid

Base Information

Chemical Name:6-Chloro-2,4-dimethylnicotinic acid
CAS No.:630082-81-4
Molecular Formula:C8H8ClNO2
Molecular Weight:185.61
Hs Code.:
DSSTox Substance ID:DTXSID40392552
Wikidata:Q82190890

Synonyms:6-Chloro-2,4-dimethylnicotinic acid;630082-81-4;6-chloro-2,4-dimethylpyridine-3-carboxylic acid;MFCD06255138;6-Chloro-2,4-dimethylnicotinicacid;SCHEMBL2132960;DTXSID40392552;RBEYJNUECZLISX-UHFFFAOYSA-N;2,4-dimethyl-6-chloronicotinic acid;6-chloro-2,4-dimethyl-nicotinic acid;AKOS002664642;AB23712;SY265834;CS-0319678;FT-0737100

Suppliers and Price of 6-Chloro-2,4-dimethylnicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 6-Chloro-2,4-dimethylnicotinic acid

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:185.0243562
Heavy Atom Count:12
Complexity:186

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=NC(=C1C(=O)O)C)Cl

Technology Process of 6-Chloro-2,4-dimethylnicotinic acid

There total 1 articles about 6-Chloro-2,4-dimethylnicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918145-29-6
5-bromo-2-chloro-4,6-dimethylpyridine

: 124-38-9,18923-20-1
carbon dioxide

: 630082-81-4
6-chloro-2,4-dimethylpyridine-3-carboxylic acid

Guidance literature:: 5-bromo-2-chloro-4,6-dimethylpyridine; With isopropylmagnesium chloride; lithium chloride; In tetrahydrofuran; at 20 ℃; for 2.5h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; for 0.666667h; Inert atmosphere; Cooling with ice;

With hydrogenchloride; In tetrahydrofuran; water; at 30 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/op200259t

Reference yield: 98.0%

: 630082-81-4
6-chloro-2,4-dimethylpyridine-3-carboxylic acid

: 856935-52-9
(R)-[1-(3-amino-1-methyl-propyl)-piperidin-4-yl]-(4-methoxy-phenyl)-amine

: 871492-83-0
6-chloro-N-(R)-{3-[4-(4-methoxy-phenylamino)-piperidin-1-yl]-butyl}-2,4-dimethyl-nicotinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18.5h;

Reference yield: 80.0%

: 630082-81-4
6-chloro-2,4-dimethylpyridine-3-carboxylic acid

: 856938-09-5
[1-((R)-3-amino-1-methyl-propyl)-piperidin-4-yl]-(4-methoxy-phenyl)-(4-methyl-pyridin-3-ylmethyl)-amine

: 6-Chloro-N-((R)-3-{4-[(4-methoxy-phenyl)-(4-methyl-pyridin-3-ylmethyl)-amino]-piperidin-1-yl}-butyl)-2,4-dimethyl-nicotinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;