2-Methylphenyl 4-methylphenyl ether

Base Information

• Chemical Name: 2-Methylphenyl 4-methylphenyl ether
• CAS No.: 3402-72-0
• Molecular Formula: C14H14O
• Molecular Weight: 198.265
• Hs Code.: 2909309090
• Mol file: 3402-72-0.mol

Synonyms:1-methyl-2-p-tolyloxy-benzene;Benzene,1-methyl-2-(4-methylphenoxy);2-Methyl-pyrimidin-5-ol;Benzene, 1-methyl-2-(4-methylphenoxy)-;2-tolyl 4-tolyl ether;2,4'-dimethyl-diphenylether;1-methyl-2-(4-methylphenoxy)-benzene;Ether,o-tolyl p-tolyl;o-tolyl p-tolyl ether;o-Tolyl-p-tolyl-aether;

Chemical Property of 2-Methylphenyl 4-methylphenyl ether

Chemical Property:

• Vapor Pressure: 0.0066mmHg at 25°C
• Boiling Point: 280°Cat760mmHg
• Flash Point: 117.8°C
• PSA: 9.23000
• Density: 1.029g/cm³
• LogP: 4.09570

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methylphenyl 4-methylphenyl ether

There total 14 articles about 2-Methylphenyl 4-methylphenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

para-bromotoluene (106-38-7) + ortho-cresol (95-48-7,77504-84-8) → 1-methyl-2-(4-methylphenoxy)benzene (3402-72-0)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; t-BuBrettPhos; caesium carbonate; In neat (no solvent); at 110 ℃; for 18h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.mencom.2021.04.042

Reference yield: 84.0%

p-cresol (106-44-5) + 2-methylphenyl bromide (95-46-5) → 1-methyl-2-(4-methylphenoxy)benzene (3402-72-0)

Guidance literature:

With potassium carbonate; 1-Butylimidazole; copper(l) chloride; In tetradecane; toluene; at 120 ℃; for 16h; Product distribution / selectivity;

Reference yield: 82.0%

bis(4-methylphenyl)(trifluoromethanesulfonato)-λ3-iodane + ortho-cresol (95-48-7,77504-84-8) → 1-methyl-2-(4-methylphenoxy)benzene (3402-72-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 40 ℃;

DOI:10.1002/chem.201703057

upstream raw materials:

p-toluidine

ortho-cresol

para-bromotoluene

p-cresol

Downstream raw materials:

2-(4'-carboxy-phenoxy)benzoic acid

2,6-Dimethylphenoxaphosphinsaeure

p-cresol

ortho-cresol

Refernces

• 1、 Asachenko, Andrey F.,Bogachev, Vasilii N.,Cherkashchenko, Ilia R.,Lavrov, Konstantin V.,Minaeva, Lidiya I.,Nechaev, Mikhail S.,Rzhevskiy, Sergey A.,Sterligov, Grigorii K.,Topchiy, Maxim A.. "Solvent-free palladium-catalyzed C–O cross-coupling of aryl bromides with phenols". . p. 409 - 411. Retrieved 2021/06/07.
• 2、 Arokianathar, Jude N.,Kolodziejczak, Krystian,Bugden, Frances E.,Clark, Kenneth F.,Tuttle, Tell,Murphy, John A.. "Benzylic C?H Functionalisation by [Et3SiH+KOtBu] leads to Radical Rearrangements in o-tolyl Aryl Ethers, Amines and Sulfides". supporting information. p. 2260 - 2267. Retrieved 2020/05/06.