3-((benzyloxy)methyl)oxetane

Base Information

• Chemical Name: 3-((benzyloxy)methyl)oxetane
• CAS No.: 1003013-76-0
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol file: 1003013-76-0.mol

Synonyms:3-((benzyloxy)methyl)oxetane

Chemical Property of 3-((benzyloxy)methyl)oxetane

Chemical Property:

• PSA: 18.46000
• LogP: 1.84960
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-((Benzyloxy)methyl)oxetane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-((benzyloxy)methyl)oxetane

There total 4 articles about 3-((benzyloxy)methyl)oxetane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-((benzyloxy)methyl)propane-1,3-diol (117087-18-0) → 3-((benzyloxy)methyl)oxetane (1003013-76-0)

Guidance literature:

2-[(benzyloxy)methyl]propane-1,3-diol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 1h; Inert atmosphere; Cooling with ice;

With methanesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Concentration; Inert atmosphere; Cooling with ice;

Reference yield: 43.0%

3-hydroxylmethyl oxetane + benzyl bromide (100-39-0) → 3-((benzyloxy)methyl)oxetane (1003013-76-0)

Guidance literature:

3-hydroxylmethyl oxetane; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.0c03991

Reference yield:

C18H22O5S → 3-((benzyloxy)methyl)oxetane (1003013-76-0)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 25 ℃; for 1h; Heating / reflux;

upstream raw materials:

2-((benzyloxy)methyl)propane-1,3-diol

p-toluenesulfonyl chloride

benzyl bromide

Refernces

• 1、 Strassfeld, Daniel A.,Wickens, Zachary K.,Picazo, Elias,Jacobsen, Eric N.. "Highly Enantioselective, Hydrogen-Bond-Donor Catalyzed Additions to Oxetanes". supporting information. p. 9175 - 9180. Retrieved 2020/07/13.
• 2、 -. "Pyrazole glucokinase activators". Page/Page column 81-82. . Retrieved 2008/06/13.