methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate

Base Information

Chemical Name:methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate
CAS No.:1357079-85-6
Molecular Formula:C₁₁H₁₀N₂O₃
Molecular Weight:218.212
Hs Code.:
Mol file:1357079-85-6.mol

Synonyms:methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate

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Chemical Property of methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate

There total 1 articles about methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39622-79-2
2-aminoisophthalic acid

: 1357079-85-6
methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4 h / 140 °C

2.1: ammonium hydroxide; ammonium acetate / 2 h / 80 °C

3.1: sulfuric acid / Reflux

3.2: pH 6 - 7

With ammonium hydroxide; sulfuric acid; ammonium acetate;

Reference yield: 41.0%

: 1357079-85-6
methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate

: 1357080-45-5
N-[(2S)-2-amino-2-(3-chloro-4-(trifluoromethoxy)phenyl)ethyl]-N-methyl-4-nitrobenzenesulfonamide hydrochloride

: 1357080-23-9
(S)-methyl 4-((2-(4-nitro-N-methylphenylsulfonamido)-1-(3-chloro-4-(trifluoromethoxy)phenyl)ethyl)amino)-2-methylquinazoline-8-carboxylate

Guidance literature:: methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.0833333h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In 1-methyl-pyrrolidin-2-one; for 0.166667h;

N-[(2S)-2-amino-2-(3-chloro-4-(trifluoromethoxy)phenyl)ethyl]-N-methyl-4-nitrobenzenesulfonamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield:

: 1357079-85-6
methyl 2-methyl-4-oxo-3,4-dihydroquinazoline-8-carboxylate

: C₂₆H₂₄FN₅O₆S

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 14 h / 90 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/acs.jmedchem.1c01087