39622-79-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Aminoisophthalic acid is used as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs due to its reactive functional groups that facilitate chemical modifications and enhancements of drug properties.
Used in Dye Industry:
In the dye industry, 2-aminoisophthalic acid is utilized as a precursor for the production of dyes, taking advantage of its ability to form colored compounds that have specific absorption and emission characteristics, which are essential for various applications including textiles and colorants.
Used in Advanced Materials:
2-Aminoisophthalic acid is employed in the creation of advanced materials, such as high-performance polymers and composites, due to its potential to improve mechanical, thermal, and chemical properties of the resulting materials.
Used in Coordination Chemistry:
As a ligand in coordination chemistry, 2-aminoisophthalic acid is used in the formation of metal complexes, where its nitrogen and oxygen atoms serve as coordinating groups. This application is crucial for the development of catalysts, sensors, and materials with specific electronic or magnetic properties.

InChI:InChI=1/C8H7NO4/c9-6-4(7(10)11)2-1-3-5(6)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)

Upstream product

• 21161-11-5 2-nitroisophthalic acid 
• 67081-70-3 2-acetamidoisophthalic acid 
• 121732-47-6 2-benzoylamino-isophthalic acid 
• 87-62-7 2,6-dimethylaniline 
• 7647-01-0 hydrogenchloride 
• 25128-35-2 isatin-7-carboxylic acid 
• 63016-87-5 methyl 2-{[(hydroxyimino)acetyl]amino}benzoate 
• 134-20-3 2-carbomethoxyaniline 
• 81-20-9 2,6-dimethylnitrobenzene 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 2198-53-0 N-(2,6-dimethylphenyl)acetamide 

Downstream Products

• 2902-65-0 2-iodoyl-1,3-benzenedicarboxylic acid 
• 19181-77-2 4-oxo-3,4-dihydroquinazoline-8-carboxylic acid 
• 32360-46-6 2-amino-4-oxo-4H-benzo[d][1,3]oxazine-8-carboxylic acid 
• 167902-99-0 8-carboxyisatoic anhydride 
• 22433-91-6 2-bromoisophthalic acid 
• 24782-64-7 9-Oxoacridan-4-carboxylic acid 
• 1711-22-4 N-(2.3-Xylyl)2-aminoisophthalsaeure 
• 24782-65-8 7-methyl-9-oxoacridan-4-carboxylic acid 
• 40961-27-1 2-(Phenylamino)-isophthalic acid 
• 89459-28-9 7-nitro-9,10-dihydro-9-oxo-4-acridine carboxylic acid 
• 98370-37-7 2-isophthalic acid 
• 24782-66-9 9,10-dihydro-5-methyl-9-oxo-4-acridinecarboxylic acid 
• 24782-71-6 9-Oxo-7-chloracridon-4-carbonsaeure 
• 40961-29-3 5,6-dimethyl-9-oxo-9,10-dihydro-acridine-4-carboxylic acid 

Relevant academic research and scientific papers

Bisintercalating Threading Diacridines: Relationships between DNA Binding, Cytotoxicity, and Cell Cycle Arrest

We have synthesized a series of bis(9-aminoacridine-4-carboxamides) linked via the 9-position with neutral flexible alkyl chains, charged flexible polyamine chains, and a semirigid charged piperazine-containing chain. The carboxamide side chains comprise N,N-dimethylaminoethyl and ethylmorpholino groups. The compounds are designed to bisintercalate into DNA by a threading mode, in which the side chains are intended to form hydrogen-bonding contacts with the O6/N7 atoms of guanine in the major groove, and the linkers are intended to lie in the minor groove. By this means, we anticipate that they will dissociate slowly from DNA, and be cytotoxic as a consequence of template inhibition of transcription. The dimers remove and reverse the supercoiling of closed circular DNA with helix unwinding angles ranging from 26° to 46°, confirming bifunctional intercalation in all cases, and the DNA complexes of representative members dissociate many orders of magnitude more slowly than simple aminoacridines. Cytotoxicity for human leukemic CCRF-CEM cells was determined, the most active agents having IC50 values of 35-50 nM in a range extending over 20-fold, with neither the dimethylaminoethyl nor the ethylmorpholino series being intrinsically more toxic. In common with established transcription inhibitors, the morpholino series, with one exception, have no effect on cell cycle distribution in randomly dividing CCRF-CEM populations. By contrast, the dimethylaminoethyl series, with two exceptions, cause G2/M arrest in the manner of topoisomerase poisons, consistent with possible involvement of topoisomerases in their mode of action. Thus, the cellular response to these bisintercalating threading agents is complex and appears to be determined by both their side chain and linker structures. There are no simple relationships between structure, cytotoxicity, and cell cycle arrest, and the origins of this complexity are unclear given that the compounds bind to DNA by a common mechanism.

General acid catalysis in the enolization of acetone

We have used iodometry to study the enolization of acetone in water catalyzed by a series of general acids, comprised of hydrochloric acid, methanesulfonic acid, 24 aliphatic monocarboxylic acids, nine aromatic monocarboxylic acids, eight aiphatic dicarboxylic acids, and 20 monoanions of dicarboxylic acids.The log k-pK profile for unbuffered solutions of strong and moderately strong acids shows a maximum near pK ca. 0.The Broensted α value for a set of eight aliphatic monocarboxylic acids in which effects of bulk, charge, and polarizability are at a minimum is 0.56.Steric effects, probably augmented by polarizability effects in some cases, cause positive deviations from the Broensted line drawn with respect to these standard acids.Anionic carboxylic acids are also more reactive than would be predicted from their equilibrium acid strengths, whereas cationic acids tend to be less reactive.Using D2O as solvent has only a small effect on the rate of carboxylic acid catalysis.Using acetone-d6 gives values of kH/kD in the range of 7.0-8.0 at 25 deg C, values consistent with proton or deuteron being transferred between two bases of comparable strength, the carboxylate anion and the enol form of acetone.Key words: general acid catalysis, enolization, Broensted relation, steric effects, deuterium isotope effects.

Protease inhibitors

This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds, some of which are novel, of the formula: STR1 or their pharmacologically acceptable salts.

Stepwise Proton Transfer in the Acid-catalysed Hydrolysis of 3,1-Benzoxazin-4-ones: Electrostatic or hydrogen-bond Stabilisation of the Conjugate Acid

The hydrolysis of 3,1-benzoxazin-4-ones is catalyzed by buffer acids and by intramolecular carboxylic acid groups suitably placed on the heterocyclic nucleus.Small or inverse deuterium oxide solvent isotope effects on the acid catalytic terms are consistent with both inter- and intra-molecular acid catalyses proceeding through a preequilibrum protonation mechanism.Proton transfer to the N-1 position concerted with attack at C-2 is not expected because the N-1 protonated 3,1-benzoxazin-4-one is a relatively stable species.The function of the 8-carboxy-anion in the catalysed ring hydrolysis of 8-carboxy-3,1-benzoxazin-4-one is to stabilise the protonated nitrogen (N-1) by electrostatic or hydrogen-bonding interaction.