39622-79-2

Basic information

• Product Name: 2-AMINOISOPHTHALIC ACID
• Synonyms: 2,6-DicarboxyAniline;2-Aminobenzene-1,3-dicarboxylic acid, 2,6-Dicarboxyaniline;2-AMinobenzene-1,3-dicarboxylic acid;Isophthalic acid, 2-aMino-
• CAS NO: 39622-79-2
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.15
• Mol File: 39622-79-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 312-315°C
• Boiling Point: 314.24°C (rough estimate)
• Flash Point: 213.7 °C
• Appearance: /
• Density: 1.4283 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5468 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.27±0.10(Predicted)
• CAS DataBase Reference: 2-AMINOISOPHTHALIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINOISOPHTHALIC ACID(39622-79-2)
• EPA Substance Registry System: 2-AMINOISOPHTHALIC ACID(39622-79-2)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 39622-79-2(Hazardous Substances Data)

Usage

General Description

2-Aminoisophthalic acid is a chemical compound with the molecular formula C8H7NO4. It is a derivative of isophthalic acid, in which one of the hydrogen atoms on the amine group has been replaced with an amino group. It is used as a building block in the synthesis of various organic compounds and polymers. Due to its unique structural properties, 2-aminoisophthalic acid has applications in the production of pharmaceuticals, dyes, and advanced materials. It is also used as a ligand in the coordination chemistry of metal complexes, where its nitrogen and oxygen atoms can act as coordinating groups.

InChI:InChI=1/C8H7NO4/c9-6-4(7(10)11)2-1-3-5(6)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)

Upstream product

• 7647-01-0 hydrogenchloride 
• 21161-11-5 2-nitroisophthalic acid 
• 2198-53-0 N-(2,6-dimethylphenyl)acetamide 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 81-20-9 2,6-dimethylnitrobenzene 
• 134-20-3 2-carbomethoxyaniline 
• 63016-87-5 methyl 2-{[(hydroxyimino)acetyl]amino}benzoate 
• 25128-35-2 isatin-7-carboxylic acid 
• 87-62-7 2,6-dimethylaniline 
• 121732-47-6 2-benzoylamino-isophthalic acid 
• 67081-70-3 2-acetamidoisophthalic acid 

Downstream Products

• 19181-77-2 4-oxo-3,4-dihydroquinazoline-8-carboxylic acid 
• 32360-46-6 2-amino-4-oxo-4H-benzo[d][1,3]oxazine-8-carboxylic acid 
• 19181-77-2 4-hydroxyquinazoline-8-carboxylic acid 
• 98370-42-4 2-(2,5-Dimethoxy-phenylamino)-isophthalic acid 
• 98370-36-6 2-(3-Nitro-phenylamino)-isophthalic acid 
• 98370-39-9 2-(4-Nitro-phenylamino)-isophthalic acid 
• 98370-51-5 5,8-Dimethoxy-9-oxo-9,10-dihydro-acridine-4-carboxylic acid 
• 98370-28-6 2-(Biphenyl-2-ylamino)-isophthalic acid 
• 98370-41-3 2-(2-Chloro-5-methoxy-phenylamino)-isophthalic acid 
• 98370-34-4 2-(2-carboxyphenylamino)benzene-1,3-dioic acid 
• 98370-52-6 5-Chloro-8-methoxy-9-oxoacridan-4-carboxylic acid 
• 98370-40-2 2-(4-Carboxy-phenylamino)-isophthalic acid 
• 94654-61-2 8-Nitro-9-oxo-9,10-dihydro-acridine-4-carboxylic acid 
• 98370-29-7 2-(2-Methoxy-phenylamino)-isophthalic acid 

Relevant articles and documents

Bisintercalating Threading Diacridines: Relationships between DNA Binding, Cytotoxicity, and Cell Cycle Arrest

We have synthesized a series of bis(9-aminoacridine-4-carboxamides) linked via the 9-position with neutral flexible alkyl chains, charged flexible polyamine chains, and a semirigid charged piperazine-containing chain. The carboxamide side chains comprise N,N-dimethylaminoethyl and ethylmorpholino groups. The compounds are designed to bisintercalate into DNA by a threading mode, in which the side chains are intended to form hydrogen-bonding contacts with the O6/N7 atoms of guanine in the major groove, and the linkers are intended to lie in the minor groove. By this means, we anticipate that they will dissociate slowly from DNA, and be cytotoxic as a consequence of template inhibition of transcription. The dimers remove and reverse the supercoiling of closed circular DNA with helix unwinding angles ranging from 26° to 46°, confirming bifunctional intercalation in all cases, and the DNA complexes of representative members dissociate many orders of magnitude more slowly than simple aminoacridines. Cytotoxicity for human leukemic CCRF-CEM cells was determined, the most active agents having IC50 values of 35-50 nM in a range extending over 20-fold, with neither the dimethylaminoethyl nor the ethylmorpholino series being intrinsically more toxic. In common with established transcription inhibitors, the morpholino series, with one exception, have no effect on cell cycle distribution in randomly dividing CCRF-CEM populations. By contrast, the dimethylaminoethyl series, with two exceptions, cause G2/M arrest in the manner of topoisomerase poisons, consistent with possible involvement of topoisomerases in their mode of action. Thus, the cellular response to these bisintercalating threading agents is complex and appears to be determined by both their side chain and linker structures. There are no simple relationships between structure, cytotoxicity, and cell cycle arrest, and the origins of this complexity are unclear given that the compounds bind to DNA by a common mechanism.

Protease inhibitors

This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds, some of which are novel, of the formula: STR1 or their pharmacologically acceptable salts.