XEN445

Base Information

Chemical Name:XEN445
CAS No.:1515856-92-4
Molecular Formula:C18H17F3N2O3
Molecular Weight:366.3343896
Hs Code.:
Mol file:1515856-92-4.mol

Synonyms:XEN445;2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid;(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid;2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid XEN445;XEN445 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid;XEN 445, >=98%

Suppliers and Price of XEN445

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
XEN445
10mg
$ 125.00

Sigma-Aldrich
XEN445 ≥98% (HPLC)
25 mg
$ 387.00

Sigma-Aldrich
XEN445 ≥98% (HPLC)
5 mg
$ 98.60

DC Chemicals
XEN445 >98%
1 g
$ 1500.00

DC Chemicals
XEN445 >98%
250 mg
$ 750.00

CSNpharm
XEN445
50mg
$ 419.00

CSNpharm
XEN445
10mg
$ 121.00

CSNpharm
XEN445
5mg
$ 65.00

Crysdot
XEN445 98+%
10mg
$ 126.00

Crysdot
XEN445 98+%
5mg
$ 76.00

Total 25 raw suppliers

Chemical Property of XEN445

Chemical Property:

Boiling Point:490.9±45.0 °C(Predicted)
PKA:3.35±0.36(Predicted)
PSA：62.66000
Density:1.40±0.1 g/cm3(Predicted)
LogP:3.65910
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

XEN445 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50s = 20 and 9.5 μM, respectivley). An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice.
Uses XEN445 is a potent and selective endothelial lipase inhibitor.

Technology Process of XEN445

There total 1 articles about XEN445 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%