(2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

Base Information

Chemical Name:(2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
CAS No.:166247-63-8
Molecular Formula:C11H13IN4O3
Molecular Weight:376.154
Hs Code.:
European Community (EC) Number:881-340-4
ChEMBL ID:CHEMBL4540304
Nikkaji Number:J776.122H

Synonyms:166247-63-8;(2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol;7-Deaza-2'-deoxy-7-iodoadenosine;7-Deaza-7-Iodo-2'-deoxyadenosine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-iodo-;(2R,3S,5R)-5-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)oxolan-3-ol;LIIIRHQRQZIIRT-XLPZGREQSA-N;SCHEMBL6061826;CHEMBL4540304;7-Deaza-2''-deoxy-7-iodoadenosine;MFCD07778650;AKOS027322403;AM10117;HY-W048490;AS-73878;PD167447;CS-0100779;7-Deaza-7-I-2 inverted exclamation mark -dA;F16244;A897939;J-700376;4-Amino-7-(2-deoxy-beta-D-erythropentofuranosyl) -5-iodo-7H-pyrrolo[2,3-d]pyrimidine;4-Amino-7-(2-deoxy-beta-D-erythropentofuranosyl)-5-iodo-7H-pyrrolo [2,3-d]pyrimidine;4-amino-7-(2-deoxy-beta-d-erythropentofuranosyl)-5-iodo-7h-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-deoxy-|A-D-erythro-pentofuranosyl)-5-iodo-;(2R,3S,5R)-5-{4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-(hydroxymethyl)oxolan-3-ol

Suppliers and Price of (2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Iodo-2’-deoxytubercidin
50mg
$ 45.00

TRC
5-Iodo-2’-deoxytubercidin
100mg
$ 70.00

Crysdot
(2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 95+%
1g
$ 644.00

Crysdot
(2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 95+%
250mg
$ 257.00

ChemScene
7-Deaza-2'-deoxy-7-iodoadenosine 99.71%
250mg
$ 250.00

ChemScene
7-Deaza-2'-deoxy-7-iodoadenosine 99.71%
1g
$ 610.00

ChemScene
7-Deaza-2'-deoxy-7-iodoadenosine 99.71%
5g
$ 1790.00

Chemenu
7-DEAZA-7-IODO-2''-DEOXYADENOSINE 95%
1g
$ 790.00

Chemenu
7-DEAZA-7-IODO-2''-DEOXYADENOSINE 95%
250mg
$ 316.00

Biosynth Carbosynth
7-Deaza-2'-deoxy-7-iodoadenosine
500 mg
$ 175.00

Total 29 raw suppliers

Chemical Property of (2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

Chemical Property:

Boiling Point:657.4±55.0 °C(Predicted)
PKA:13.27±0.60(Predicted)
PSA：106.42000
Density:2.35±0.1 g/cm3(Predicted)
LogP:0.84000
Storage Temp.:2-8°C(protect from light)
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
XLogP3:0.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:376.00324
Heavy Atom Count:19
Complexity:337

Purity/Quality:

98%, ^*data from raw suppliers

5-Iodo-2’-deoxytubercidin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C=C(C3=C(N=CN=C32)N)I)CO)O
Isomeric SMILES:C1[C@@H]([C@H](O[C@H]1N2C=C(C3=C(N=CN=C32)N)I)CO)O
Uses 5-Iodo-2’-deoxytubercidin is a derivative of 7-Iodo-7-deazadenine designed to be incorporated into DNA by primers extension by using Vent(exo-) polymerase. Possesses photophysical properties.

Technology Process of (2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

There total 5 articles about (2R,3S,5R)-5-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (2R,3S,5R)-5-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((4-chlorobenzoyloxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate

: 166247-63-8,908130-61-0
7-deaza-2'-deoxy-7-iodoadenosine

Guidance literature:: (2R,3S,5R)-5-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((4-chlorobenzoyloxy)methyl)tetrahydrofuran-3-yl 4-chlorobenzoate; With ammonia; In methanol; at 0 - 100 ℃; for 0.5h;

In methanol; at 100 ℃; for 24h; Sealed tube;
DOI:10.1139/cjc-2018-0303