6-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ethyl ester

Base Information

Chemical Name:6-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ethyl ester
CAS No.:29954-04-9
Molecular Formula:C₁₂H₁₀BrNO₃
Molecular Weight:296.12
Hs Code.:
Mol file:29954-04-9.mol

Synonyms:6-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ethyl ester

Suppliers and Price of 6-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ethyl ester

Chemical Property:

PSA：59.16000
LogP:2.46730

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ethyl ester

There total 5 articles about 6-Bromo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1238054-87-9
2-(4-Bromophenylamino)but-2-enedioic acid diethyl ester

: 29954-04-9
6-bromo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid ethyl ester

Guidance literature:: With phosphorus pentoxide; In methanesulfonic acid; at 55 ℃; for 1h;
DOI:10.1016/j.tet.2014.11.018

Reference yield:

: 106-40-1
4-bromo-aniline

: 29954-04-9
6-bromo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 5 h / Reflux

2: phosphorus pentoxide / methanesulfonic acid / 1 h / 55 °C

With phosphorus pentoxide; In methanesulfonic acid; ethanol;
DOI:10.1016/j.tet.2014.11.018

Reference yield:

: 106-40-1
4-bromo-aniline

: 762-21-0
acetylenedicarboxylic acid diethyl ester

: 29954-04-9
6-bromo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: neat (no solvent) / 20 °C / Green chemistry

2: polyphosphoric acid / neat (no solvent) / 90 °C / Inert atmosphere; Green chemistry

With polyphosphoric acid; In neat (no solvent); 2: |Friedel-Crafts Acylation;
DOI:10.1016/j.tetlet.2015.04.060