Acetamide, N-(3-amino-2,6-difluorophenyl)-

Base Information

• Chemical Name: Acetamide, N-(3-amino-2,6-difluorophenyl)-
• CAS No.: 946826-47-7
• Molecular Formula: C8H8F2N2O
• Molecular Weight: 186.161
• Hs Code.: 2924297099
• Mol file: 946826-47-7.mol

Synonyms:Acetamide, N-(3-amino-2,6-difluorophenyl)-;N-(3-aMino-2,6-difluorophenyl)acetaMide

Chemical Property of Acetamide, N-(3-amino-2,6-difluorophenyl)-

Chemical Property:

• PSA: 58.61000
• LogP: 2.73610
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

N-(3-Amino-2,6-difluorophenyl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, N-(3-amino-2,6-difluorophenyl)-

There total 3 articles about Acetamide, N-(3-amino-2,6-difluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(2,6-difluoro-3-nitrophenyl)acetamide (25892-08-4) → N-(3-amino-2,6-difluorophenyl)acetamide (946826-47-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.03.055

Reference yield:

N-(2,6-difluorophenyl)acetamide (3896-29-5) → N-(3-amino-2,6-difluorophenyl)acetamide (946826-47-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium nitrate; sulfuric acid / 2 h / -10 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 10343.2 Torr / Autoclave

With sulfuric acid; hydrogen; potassium nitrate; palladium 10% on activated carbon; In methanol;

Reference yield:

2,6-difluoroaniline (5509-65-9) → N-(3-amino-2,6-difluorophenyl)acetamide (946826-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 16 h / 20 °C

2: nitric acid; sulfuric acid / 18 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C / Inert atmosphere

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; In ethanol; dichloromethane;

DOI:10.1016/j.bmc.2016.03.055

upstream raw materials:

N-(2,6-difluorophenyl)acetamide

N-(2,6-difluoro-3-nitrophenyl)acetamide

2,6-difluoroaniline

Downstream raw materials:

N-(2,6-difluoro-3-(propylsulfonamido)phenyl)acetamide

C₉H₁₂F₂N₂O₂S*ClH

N-(3-(5-((1-ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin- 1-yl)-2,4-difluorophenyl)propane-1-sulfonamide

N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)benzenesulfonamide