IMidodicarbonic acid, 2-(5-hydroxy-2-pyriMidinyl)-, 1,3-bis(1,1-diMethylethyl) ester

Base Information

• Chemical Name: IMidodicarbonic acid, 2-(5-hydroxy-2-pyriMidinyl)-, 1,3-bis(1,1-diMethylethyl) ester
• CAS No.: 914377-34-7
• Molecular Formula: C₁₄H₂₁N₃O₅
• Molecular Weight: 311.338
• Mol file: 914377-34-7.mol

Synonyms:IMidodicarbonic acid, 2-(5-hydroxy-2-pyriMidinyl)-, 1,3-bis(1,1-diMethylethyl) ester;tert-butyl N-[(tert-butoxy)carbonyl]-N-(5-hydroxypyrimidin-2-yl)carbamate;Di-tert-butyl (5-hydroxypyrimidin-2-yl)imidodicarbonate

Chemical Property of IMidodicarbonic acid, 2-(5-hydroxy-2-pyriMidinyl)-, 1,3-bis(1,1-diMethylethyl) ester

Chemical Property:

• PSA: 101.85000
• LogP: 2.85880

Purity/Quality:

99%, ^*data from raw suppliers

2-(5-Hydroxy-2-pyrimidinyl)imidodicarbonicAcid1,3-Bis(1,1-dimethylethyl)Ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-(5-Hydroxy-2-pyrimidinyl)imidodicarbonic Acid 1,3-Bis(1,1-dimethylethyl) Ester was used in the synthesis of substituted pyrimidinamines which may act as selective NR2B antagonists.

Technology Process of IMidodicarbonic acid, 2-(5-hydroxy-2-pyriMidinyl)-, 1,3-bis(1,1-diMethylethyl) ester

There total 2 articles about IMidodicarbonic acid, 2-(5-hydroxy-2-pyriMidinyl)-, 1,3-bis(1,1-diMethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-[bis(tert-butoxycarbonyl)amino]-5-bromopyrimidine (209959-33-1) → 2-(5-hydroxy-2-pyrimidinyl)imidodicarbonic acid 1,3-bis(1,1-dimethylethyl)ester (914377-34-7)

Guidance literature:

2-[bis(tert-butoxycarbonyl)amino]-5-bromopyrimidine; With potassium acetate; bis(pinacol)diborane; palladium diacetate; In N,N-dimethyl-formamide;

With sodium perborate; In tetrahydrofuran; water;

DOI:10.1016/j.tetlet.2006.08.018

Reference yield: 70.0%

di-tert-butyl (5-(benzyloxy)pyrimidin-2-yl)biscarbamate (1428558-29-5) → 2-(5-hydroxy-2-pyrimidinyl)imidodicarbonic acid 1,3-bis(1,1-dimethylethyl)ester (914377-34-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 18h;

upstream raw materials:

2-[bis(tert-butoxycarbonyl)amino]-5-bromopyrimidine

di-tert-butyl (5-(benzyloxy)pyrimidin-2-yl)biscarbamate

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