(S)-2-(Chloromethyl)pyrrolidine hydrochloride

Base Information

• Chemical Name: (S)-2-(Chloromethyl)pyrrolidine hydrochloride
• CAS No.: 35120-33-3
• Molecular Formula: C5H11Cl2N
• Molecular Weight: 0
• European Community (EC) Number: 886-806-0
• DSSTox Substance ID: DTXSID40544579
• Mol file: 35120-33-3.mol

Synonyms:35120-33-3;(S)-2-(Chloromethyl)pyrrolidine hydrochloride;(S)-2-CHLOROMETHYL-PYRROLIDINE HYDROCHLORIDE;(2S)-2-(chloromethyl)pyrrolidine hydrochloride;(2S)-2-(chloromethyl)pyrrolidine;hydrochloride;DTXSID40544579;MFCD09701399;AKOS016009305;AM100703;(S)-2-(Chloromethyl)pyrrolidinehydrochloride;CS-0215002;EN300-213017;(2S)-2-(Chloromethyl)pyrrolidine--hydrogen chloride (1/1);(S)-2-(Chloromethyl)pyrrolidine hydrochloride, AldrichCPR

Chemical Property of (S)-2-(Chloromethyl)pyrrolidine hydrochloride

Chemical Property:

• Melting Point: 137-138℃
• PSA: 12.03000
• LogP: 2.10800
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 155.0268547
• Heavy Atom Count: 8
• Complexity: 56

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-Chloromethyl-pyrrolidinehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(NC1)CCl.Cl
• Isomeric SMILES: C1C[C@H](NC1)CCl.Cl

Technology Process of (S)-2-(Chloromethyl)pyrrolidine hydrochloride

There total 1 articles about (S)-2-(Chloromethyl)pyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → (S)-2-(chloromethyl)pyrrolidine hydrochloride (35120-33-3)

Guidance literature:

With hydrogenchloride; thionyl chloride; In chloroform;

DOI:10.1016/j.bmcl.2003.11.032

Reference yield: 99.0%

2,2'-dithiodibenzoic acid dichloride (19602-82-5) + (S)-2-(chloromethyl)pyrrolidine hydrochloride (35120-33-3) → (S)-bis<2-<<2-(chloromethyl)-1-pyrrolidinyl>carbonyl>phenyl> disulphide (121451-45-4)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1002/jhet.5570250358

Reference yield: 94.0%

(S)-2-(chloromethyl)pyrrolidine hydrochloride (35120-33-3) + benzyl chloroformate (501-53-1,94274-21-2) → (S)-2-(chloromethyl)-1-pyrrolidinecarboxylic acid phenylmethyl ester (61350-66-1,1187932-05-3)

Guidance literature:

With triethylamine; at 0 ℃;

DOI:10.1016/j.bmcl.2003.11.032

upstream raw materials:

(S)-1-Pyrrolidin-2-yl-methanol

Downstream raw materials:

(S)-bis<2-<<2-(chloromethyl)-1-pyrrolidinyl>carbonyl>phenyl> disulphide

(S)-2-(chloromethyl)-1-pyrrolidinecarboxylic acid phenylmethyl ester