5-Methoxy-2,3-dihydroquinolin-4(1H)-one

Base Information

• Chemical Name: 5-Methoxy-2,3-dihydroquinolin-4(1H)-one
• CAS No.: 3835-23-2
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.203
• DSSTox Substance ID: DTXSID70487460
• Wikidata: Q82329482
• Mol file: 3835-23-2.mol

Synonyms:61999-48-2;5-METHOXY-2,3-DIHYDROQUINOLIN-4(1H)-ONE;4(1H)-Quinolinone, 2,3-dihydro-5-methoxy-;2,3-DIHYDRO-5-METHOXY-4(1H)-QUINOLINONE;Oprea1_547220;DTXSID70487460;AKOS006277753;AB11870

Chemical Property of 5-Methoxy-2,3-dihydroquinolin-4(1H)-one

Chemical Property:

• PSA: 38.33000
• LogP: 1.83150
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.078978594
• Heavy Atom Count: 13
• Complexity: 205

Purity/Quality:

99% ^*data from raw suppliers

2,3-DIHYDRO-8-METHOXY-4(1H)-QUINOLINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1C(=O)CCN2

Technology Process of 5-Methoxy-2,3-dihydroquinolin-4(1H)-one

There total 9 articles about 5-Methoxy-2,3-dihydroquinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(2-methoxyphenyl)azetidin-2-one (1309606-50-5) → 1,2,3,4-tetrahydro-8-methoxyquinolin-4-one (3835-23-2)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 0 - 18 ℃; for 1h; Inert atmosphere;

DOI:10.1071/CH10465

Reference yield: 66.0%

2,3-dihydro-8-methoxy-1-tosyl-4(1H)-quinoline (3536-04-7) → 1,2,3,4-tetrahydro-8-methoxyquinolin-4-one (3835-23-2)

Guidance literature:

With hydrogenchloride; acetic acid; for 3.5h; Heating;

DOI:10.1016/0223-5234(93)90036-E

Reference yield: 58.0%

3-[(2-methoxyphenyl)amino]propanoic acid (3334-66-5) → 1,2,3,4-tetrahydro-8-methoxyquinolin-4-one (3835-23-2)

Guidance literature:

With PPA; at 150 ℃;

DOI:10.1081/SCC-200026212

upstream raw materials:

2,3-dihydro-8-methoxy-1-tosyl-4(1H)-quinoline

3-[(2-methoxyphenyl)amino]propanoic acid

methyl 3-[(2-methoxyphenyl)amino]propanoate

2-methoxy-phenylamine

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