3334-66-5Relevant academic research and scientific papers
2,3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivatives as well as preparation method and application thereof
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Paragraph 0076-0079; 0149-0152, (2019/04/04)
The invention discloses 2,3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivatives as well as a preparation method and application thereof. The structural formula of the derivatives is as shown in a formula (I): (the formula is as shown in the description), wherein R1 is halogen, alkyl or alkoxy; R2 is hydrogen, halogen or alkoxy; R3 is hydrogen or halogen; R4 is hydrogen or halogen; X is hydrogen, acetyl or nitryl; and Y is hydrogen or phenyl. The derivatives can obviously inhibit proliferation of tumor cells, and has significant inhibition effect on multiple cancer cell strains such asbreast cancer cells, melanoma cells and prostatic cancer cells; and the anti-tumor activity is obviously better than that of a broad-spectrum anti-cancer medicine cis-platinum. In addition, the preparation process of the derivatives is simple, the conditions are mild, the sources of the raw materials are rich, the production cost is low, and potential medicinal value and good application prospectin the aspect of preparing a novel anti-tumor medicine are achieved.
ANTIVIRAL COMPOUNDS
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, (2018/04/13)
The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.
A regioselective synthesis of tetrahydrobenzodiazepin-5-ones via the Schmidt rearrangement of quinolones
Tapia, Ricardo A.,Centella, Cesar
, p. 2757 - 2765 (2007/10/03)
The regioselective synthesis of 2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-5- ones by the Schmidt rearrangement of 1,2,3,4-tetrahydro-4-quinolones with oxygen substituents at C-8 is described.
