D-2-INDANYLGLYCINE

Base Information

• Chemical Name: D-2-INDANYLGLYCINE
• CAS No.: 181227-46-3
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Mol file: 181227-46-3.mol

Synonyms:H-D-(2-INDA)GLY-OH;H-D-(2-INDANYL)GLY-OH;D-2-INDANYLGLYCINE;(R)-2-AMino-2-(2,3-dihydro-1H-inden-2-yl)acetic acid

Chemical Property of D-2-INDANYLGLYCINE

Chemical Property:

• PSA: 63.32000
• LogP: 1.51360

Purity/Quality:

98.5% ^*data from raw suppliers

(R)-2-Amino-2-(2,3-dihydro-1H-inden-2-yl)aceticacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-2-INDANYLGLYCINE

There total 12 articles about D-2-INDANYLGLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C19H21NO4 → (2R)-amino(2,3-dihydro-1H-inden-2-yl)ethanoic acid (181227-46-3,155239-51-3,16655-71-3)

Guidance literature:

With palladium on activated charcoal; In methanol; at 50 ℃; for 12h; Reagent/catalyst;

Reference yield: 88.0%

C19H21NO3 → (2R)-amino(2,3-dihydro-1H-inden-2-yl)ethanoic acid (181227-46-3,155239-51-3,16655-71-3)

Guidance literature:

With palladium 10% on activated carbon; In methanol; at 50 ℃; for 12h; Concentration; Temperature; Reagent/catalyst;

Reference yield: 63.0%

(R)-((R)-1-Oxo-indan-2-yl)-((R)-1-phenyl-ethylamino)-acetic acid (847153-94-0) → (2R)-amino(2,3-dihydro-1H-inden-2-yl)ethanoic acid (181227-46-3,155239-51-3,16655-71-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In hydrogenchloride; methanol;

DOI:10.1016/j.tetlet.2004.12.048

upstream raw materials:

(R)-((R)-1-Oxo-indan-2-yl)-((R)-1-phenyl-ethylamino)-acetic acid

(R)-N-carbamylindanylglycine

rac-indanylglycine hydantoin

tert-butyl N-(diphenylmethylene)-2-(2-indanyl)glycinate

Downstream raw materials:

C₃₂H₃₆N₄O₄

2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,5-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamide

2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(1-ethylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)-2-(6-methyl-3-pyridinyl)acetamide

2-[(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-(2,2-dimethylpropyl)-2,5-dioxo-1-piperazinyl]-N-(2-hydroxyphenyl)-2-(6-methyl-3-pyridinyl)acetamide

Refernces

• 1、 -. "Method for preparing D-indanyl glycine". . . Retrieved 2018/04/01.
• 2、 Kolarovi?, Andrej,Berke?, Du?an,Baran, Peter,Pova?anec, Franti?ek. "Crystallization-induced asymmetric transformation (CIAT) with simultaneous epimerization at two stereocenters. A short synthesis of conformationally constrained homophenylalanines". . p. 975 - 978. Retrieved 2007/10/03.