1-Boc-4-(1,2,3,4-tetrahydroisoquinolin-8-yl)piperazine

Base Information

• Chemical Name: 1-Boc-4-(1,2,3,4-tetrahydroisoquinolin-8-yl)piperazine
• CAS No.: 444620-34-2
• Molecular Formula: C18H27N3O2
• Molecular Weight: 317.431
• Hs Code.: 2933990090
• Mol file: 444620-34-2.mol

Synonyms:1-Boc-4-(1,2,3,4-tetrahydroisoquinolin-8-yl)piperazine

Chemical Property of 1-Boc-4-(1,2,3,4-tetrahydroisoquinolin-8-yl)piperazine

Chemical Property:

• Vapor Pressure: 2.41E-09mmHg at 25°C
• Boiling Point: 479.2°C at 760 mmHg
• Flash Point: 243.6°C
• PSA: 44.81000
• Density: 1.122g/cm³
• LogP: 2.72110
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

tert-Butyl4-(1,2,3,4-tetrahydroisoquinolin-8-yl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-(1,2,3,4-tetrahydroisoquinolin-8-yl)piperazine

There total 3 articles about 1-Boc-4-(1,2,3,4-tetrahydroisoquinolin-8-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-bromo-isoquinoline (63927-22-0) → 4-(1,2,3,4-tetrahydro-isoquinolin-8-yl)-piperazine-1-carboxylic acid tert-butyl ester (444620-34-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOAc; BINAP; Pd(dba)2

2: H₂ / Pt

With hydrogen; sodium acetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾; platinum;

DOI:10.1016/j.bmcl.2005.07.035

Reference yield:

4-isoquinolin-8-yl-piperazine-1-carboxylic acid tert-butyl ester (444620-33-1) → 4-(1,2,3,4-tetrahydro-isoquinolin-8-yl)-piperazine-1-carboxylic acid tert-butyl ester (444620-34-2)

Guidance literature:

With hydrogen; platinum;

DOI:10.1016/j.bmcl.2005.07.035

Reference yield:

8-(piperazin-1-yl)isoquinoline (105685-27-6) → 4-(1,2,3,4-tetrahydro-isoquinolin-8-yl)-piperazine-1-carboxylic acid tert-butyl ester (444620-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pt

With hydrogen; platinum;

DOI:10.1016/j.bmcl.2005.07.035

upstream raw materials:

4-isoquinolin-8-yl-piperazine-1-carboxylic acid tert-butyl ester

8-(piperazin-1-yl)isoquinoline

8-bromo-isoquinoline

Downstream raw materials:

2-benzenesulfonyl-8-piperazin-1-yl-1,2,3,4-tetrahydro-isoquinoline

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