63927-22-0

Basic information

• Product Name: 8-Bromoisoquinoline
• Synonyms: 8-BROMOISOQUINOLINE;8-Bromoisoquinoline 95%;Isoquinoline, 8-bromo-;8-Bromoisoquinoline ,97%
• CAS NO: 63927-22-0
• Molecular Formula: C₉H₆BrN
• Molecular Weight: 208.05
• EINECS: -0
• Product Categories: blocks;Bromides;Heterocycles;Quinolines;Quinoline series;Heterocyclic Series;Halides;Quinolines, Isoquinolines & Quinoxalines;Quinoline&Isoquinoline;Isoquinoline Derivertives;Building Blocks;Isoquinoline;Quinolines, Isoquinolines & Quinoxalines;C8 to C10;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis
• Mol File: 63927-22-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 80,5 C
• Boiling Point: 312.3 °C at 760 mmHg
• Flash Point: 142.7 °C
• Appearance: /
• Density: 1.564 g/cm³
• Vapor Pressure: 0.0101mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.63±0.23(Predicted)
• CAS DataBase Reference: 8-Bromoisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Bromoisoquinoline(63927-22-0)
• EPA Substance Registry System: 8-Bromoisoquinoline(63927-22-0)

Safety Data

• Hazard Codes: Xi,Xn,T
• Statements: 36/37/38-20/21/22-25
• Safety Statements: 26-36-45
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 63927-22-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow powder

Uses

8-Bromoisoquinoline is an intermediate used to prepare 4-?((2-?Hydroxy-?3-?methoxybenzyl)?amino)?benzenesulfonamide derivatives as potent and selective inhibitors of 12-?Lipoxygenase. It is also used in the synthesis of selective excitatory amino acid transporter subtype 1 (EAAT1) Inhibitor UCPH-?102.

InChI:InChI=1/C12H13N/c1-9(2)12-11-6-4-3-5-10(11)7-8-13-12/h3-9H,1-2H3

Upstream product

• 7664-93-9 sulfuric acid 
• 63927-19-5 (2-bromo-benzylidenamino)-acetaldehyde diethylacetal 
• 119-65-3 isoquinoline 
• 405161-29-7 (2-bromobenzylidene)(2,2-dimethoxyethyl)amine 
• 23687-27-6 8-aminoisoquinoline 
• 34784-04-8 5-bromoisoquinoline 
• 6630-33-7 ortho-bromobenzaldehyde 
• 22483-09-6 2,2-dimethoxyethylamine 
• 1239460-78-6 2-bromo-N-(2,2-dimethyloxyethylidene)aniline 
• 3132-99-8 m-bromobenzoic aldehyde 
• 14000-31-8 pyrophosphoric acid 
• 645-36-3 2,2-diethoxy-ethanamine 
• 63927-23-1 5-bromo-8-nitroisoquinoline 

Downstream Products

• 362606-11-9 isoquinoline-8-carbonitrile 
• 475994-58-2 8-bromo-2-oxidoisoquinolin-2-ium 
• 105685-27-6 8-(piperazin-1-yl)isoquinoline 
• 863290-47-5 2-benzoyl-8-bromo-1-cyano-1,2-dihydroisoquinoline 
• 1239460-79-7 tert-butyl 2-(isoquinolin-8-yl)acetate 

Relevant articles and documents

ISOXAZOLINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS

Disclosed are compounds of Formula 1, wherein R1, R2, R3 and J are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.

INHIBITORS OF JUN N-TERMINAL KINASE

The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula (I): or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine

The synthesis and the 125I-apamin binding studies of original C-5- and C-8-substituted 1-(3,4-dimethoxy-benzyl)-2,2-dimethyl-1,2,3,4- tetrahydroisoquinoliniums and 1-(3,4-dimethoxy-benzyl)-6,6-dimethyl-4,5,6,7- tetrahydrothieno[2,3-c]pyridiniums were performed in order to find a reversible and selective SK channel blocker structurally related to N-methyl-laudanosine and N-methyl-noscapine. A bulky alkyl substituent in the C-8 position of the tetrahydroisoquinoline produces a clear increase in the affinity for the apamin sensitive binding sites. The presence of an electron-withdrawing group in the C-5 and C-8 positions is not a suitable substitution for the affinity of drugs structurally related to N-methyl-laudanosine. Thiophenic analogues and 8-methoxy derivatives possess a poor affinity for the apamin sensitive binding sites. Electrophysiological studies performed with the most effective compound showed a blockade of the apamin sensitive afterhyperpolarization in rat dopaminergic neurons.