Technology Process of (2S,3S,5R)-3-AZIDO-N-(3-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)PROPYL)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE
There total 2 articles about (2S,3S,5R)-3-AZIDO-N-(3-((1S,2S,3S,5R,6R)-3,5-DIAZIDO-2-((2S,3R,4R,5S,6R)-3-AZIDO-6-(AZIDOMETHYL)-4,5-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLAMINO)PROPYL)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-2-CARBOXAMIDE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
epi-5-(3-aminopropyl)-amino-1,3,2',6'-tetraazido neamine; 4’-carboxylic acid-3’-azido-3’-deoxythymidine;
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 20h;
With
potassium carbonate;
In
methanol;
at 20 ℃;
for 2h;
Further stages.;
DOI:10.1016/j.tet.2007.06.002
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: CH2Cl2; pyridine / 1.5 h / 20 °C
1.2: 60 percent / tetrahydrofuran / 24 h / 20 °C
2.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 20 h / 20 °C
2.2: 91 percent / K2CO3 / methanol / 2 h / 20 °C
With
benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.06.002
- Guidance literature:
-
With
hydrogen sulfide;
In
pyridine; water; triethylamine;
at 20 ℃;
for 1h;
DOI:10.1016/j.tet.2007.06.002
