(2,4-diMethylphenyl)(2-nitrophenyl)sulfane

Base Information

• Chemical Name: (2,4-diMethylphenyl)(2-nitrophenyl)sulfane
• CAS No.: 1610527-49-5
• Molecular Formula: C14H13NO2S
• Molecular Weight: 259.32352
• Mol file: 1610527-49-5.mol

Synonyms:(2,4-diMethylphenyl)(2-nitrophenyl)sulfane;2,4-Dimethyl-1-[(2-nitrophenyl)thio]benzene

Chemical Property of (2,4-diMethylphenyl)(2-nitrophenyl)sulfane

Chemical Property:

• Boiling Point: 353.9±30.0 °C(Predicted)
• PSA: 71.12000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 4.88600
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

HPLC>99% ^*data from raw suppliers

(2,4-Dimethylphenyl)(2-nitrophenyl)sulfane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (2,4-Dimethylphenyl)(2-nitrophenyl)sulfane is a reacatnat in studying generic industry approach to efficient purification of potential mutagenic impurities in the synthesis of drug substances.

Technology Process of (2,4-diMethylphenyl)(2-nitrophenyl)sulfane

There total 9 articles about (2,4-diMethylphenyl)(2-nitrophenyl)sulfane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-dimethyl-thiophenol (13616-82-5) + 2-Chloronitrobenzene (88-73-3) → 2,4-dimethyl-1-[(2-nitro-phenyl)-sulfanyl]-benzene (1610527-49-5)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 50 ℃; for 5h;

Reference yield: 98.0%

2,4-dimethyl-thiophenol (13616-82-5) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 2,4-dimethyl-1-[(2-nitro-phenyl)-sulfanyl]-benzene (1610527-49-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 2.5h;

Reference yield: 89.6%

1-iodo-2,4-dimethylbenzene (4214-28-2) + o-nitrothiophenol (4875-10-9) → 2,4-dimethyl-1-[(2-nitro-phenyl)-sulfanyl]-benzene (1610527-49-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 2h; Reagent/catalyst; Solvent;

upstream raw materials:

2,4-dimethyl-thiophenol

2-Chloronitrobenzene

ortho-nitrofluorobenzene

1-iodo-2,4-dimethylbenzene

Downstream raw materials:

vortioxetine

Vortioxetine hydrochloride

Vortioxetine hydrobromide

(2′-bromophenyl)(2,4-dimethylphenyl)sulfane

Refernces

• 1、 -. "Preparation method of 1-[2-(2, 4-dimethylthiophenyl)-phenyl]piperazine". Paragraph 0022-0026. . Retrieved 2020/07/12.
• 2、 -. "AN IMPROVED PROCESS FOR PREPARATION AND PURIFICATION OF VORTIOXETINE HYDROBROMIDE". Page/Page column 9. . Retrieved 2018/09/19.