4214-28-2

Basic information

• Product Name: 4-IODO-M-XYLENE
• Synonyms: 1-iodo-2,4-dimethyl-benzen;Benzene, 1-iodo-2,4-dimethyl-;m-Xylene, 4-iodo-;4-Iodo-3-xylene;2,4-Dimethyliodobenzene, 98+%;2,4-Dimethylphenyl iodide;4-Iodo-m-xylene,95%;2,4-Dimethyliodobenzene 98%
• CAS NO: 4214-28-2
• Molecular Formula: C₈H₉I
• Molecular Weight: 232.06
• EINECS: 224-141-4
• Product Categories: Halogen toluene;Iodine Compounds
• Mol File: 4214-28-2.mol
• Article Data: 41

Chemical Properties

• Melting Point: -2.9°C (estimate)
• Boiling Point: 105-106 °C5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow/Liquid
• Density: 1.628 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: n20/D 1.598(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Not miscible or difficult to mix in water.
• Sensitive: Light Sensitive
• BRN: 1422602
• CAS DataBase Reference: 4-IODO-M-XYLENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-M-XYLENE(4214-28-2)
• EPA Substance Registry System: 4-IODO-M-XYLENE(4214-28-2)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-36-24/25-37
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 4214-28-2(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow liquid

Uses

4-Iodo-m-xylene is a reactant used in the preparation of paralog-selective Hsp90 inhibitors.

InChI:InChI=1/C8H9I/c1-6-3-4-8(9)7(2)5-6/h3-5H,1-2H3

Upstream product

• 108-38-3 m-xylene 
• 95-47-6 o-xylene 
• 7697-37-2 nitric acid 
• 7553-56-2 iodine 
• 64-19-7 acetic acid 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 137-07-5 2-amino-benzenethiol 
• 54958-15-5 bis(2,4-dimethylphenyl)iodonium bromide 
• 1141-88-4 2-Aminophenyl disulfide 
• 88-61-9 2,4-dimethylbenzenesulfonic acid 
• 95-68-1 2,4-Xylidine 

Downstream Products

• 59696-36-5 (2,4-dimethylphenyl)-λ³-iodanediyl diacetate 
• 102751-84-8 4,6,2',4'-tetramethyl-biphenyl-2-sulfonic acid phenyl ester 
• 4102-50-5 4,6-diiodo-1,3-xylene 
• 31599-52-7 2,4-dimethyl(dichloroiodo)benzene 
• 4102-38-9 1-iodo-2,4-dimethyl-5-nitro-benzene 
• 97151-77-4 9,10-bis-(2,4-dimethyl-phenyl)-9,10-dihydro-anthracene-9,10-diol 
• 87895-61-2 2-amino-2',4'-dimethylbenzophenone 
• 21789-36-6 2,4-dimethylbenzonitrile 
• 97848-36-7 bis-(2,4-dimethyl-phenyl)-telluride 
• 81863-88-9 α,α'-dibromo-4-iodo-m-xylene 
• 66252-69-5 2,7-Bis(2,4-dimethylphenyl)-9H-fluoren 
• 108-38-3 m-xylene 
• 41496-45-1 3-(2’,4’-dimethyphenyl)propanal 
• 37560-43-3 1-(2,4-dimethylphenyl)-1H-pyrrole 

Relevant articles and documents

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R4NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and beyond

A new convenient and versatile halogenating system (R4NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.

A simple and efficient iodination of aromatic compounds using I2/Choline Chloride/K2S2O8

A simple and efficient method for the iodination of aromatic compounds has been achieved in the presence of molecular iodine, choline chloride and potassium peroxodisulfate at 65 °C in acetonitrile. The rate of conversion of aromatic compounds into iodoaromatic compounds was promoted by in situ formed choline peroxodisulfate. This protocol provides an efficient access to iodoarenes with operational simplicity, good functional group tolerance and a moderate to good product yield.

An efficient gram scale synthesis of aryl iodides from aryl diazofluoroborates in water under mild conditions

Transition metal-free synthesis of synthetically valuable aryl iodides from aryl diazofluroborates in water under mild conditions has been described. Majority of synthesized aryl iodides are obtained in quantitative yields (>99%) under present reaction conditions. The structural effects due to the substituents present on aryl diazofluoroborates did not show any satisfactory effect on the yields of the aryl iodides. Hence, the methodology presented here was found to be adventitious for the quantitative production of synthetically valuable aryl iodides.