(2-aMino-6-chloropyridin-4-yl)Methanol

Base Information

• Chemical Name: (2-aMino-6-chloropyridin-4-yl)Methanol
• CAS No.: 1334294-36-8
• Molecular Formula: C6H7ClN2O
• Molecular Weight: 158.587
• Mol file: 1334294-36-8.mol

Synonyms:(2-aMino-6-chloropyridin-4-yl)Methanol

Chemical Property of (2-aMino-6-chloropyridin-4-yl)Methanol

Chemical Property:

• PSA: 59.14000
• LogP: 1.39070

Purity/Quality:

NLT 98% ^*data from raw suppliers

(2-Amino-6-chloropyridin-4-yl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-aMino-6-chloropyridin-4-yl)Methanol

There total 2 articles about (2-aMino-6-chloropyridin-4-yl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-amino-6-chloropyridine-4-carboxylic acid (6313-55-9) → (2-amino-6-chloropyridin-4-yl)methanol (1334294-36-8)

Guidance literature:

2-amino-6-chloropyridine-4-carboxylic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With water; potassium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

2,6-dichloropyridine-4-carboxylic acid (5398-44-7) → (2-amino-6-chloropyridin-4-yl)methanol (1334294-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonia / water / 8 h / 165 °C / 14251.4 Torr / Sealed tube; Microwave irradiation

1.2: pH 3

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 0 - 20 °C

With lithium aluminium tetrahydride; ammonia; In tetrahydrofuran; water;

Reference yield:

(2-amino-6-chloropyridin-4-yl)methanol (1334294-36-8) → trans-4-[(4-(hydroxymethyl)-6-{[6-(1H-pyrazol-4-yl)-1,3-benzothiazol-2-yl]amino}-2-pyridinyl)amino]cyclohexanol

Guidance literature:

Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere; Cooling with ice; Reflux

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4: 2 h / 200 °C / Sealed tube; Microwave irradiation

5: caesium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 150 °C / Sealed tube; Microwave irradiation

With 1H-imidazole; tetrabutyl ammonium fluoride; water; sodium hydride; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2,6-dichloropyridine-4-carboxylic acid

2-amino-6-chloropyridine-4-carboxylic acid

Refernces

• 1、 -. "DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES". . . Retrieved 2011/10/05.