1-METHYL-4-[[2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]METHYL]-PIPERAZINE

Base Information

• Chemical Name: 1-METHYL-4-[[2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]METHYL]-PIPERAZINE
• CAS No.: 440652-32-4
• Molecular Formula: C₁₈H₂₉BN₂O₂
• Molecular Weight: 316.251
• Mol file: 440652-32-4.mol

Synonyms:1-METHYL-4-[[2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]METHYL]-PIPERAZINE

Chemical Property of 1-METHYL-4-[[2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]METHYL]-PIPERAZINE

Chemical Property:

• Boiling Point: 420.4±35.0 °C(Predicted)
• PKA: 7.60±0.10(Predicted)
• Density: 1.06±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

1-METHYL-4-(2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZYL)PIPERAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-METHYL-4-[[2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]METHYL]-PIPERAZINE

There total 2 articles about 1-METHYL-4-[[2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]METHYL]-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + benzyl bromide (100-39-0) → 1-methyl-4-[[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]piperazine (440652-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: bis(η⁴-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I) / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere; Glovebox; Sealed tube

With bis(η⁴-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I); potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/acs.joc.2c00046

Reference yield:

→ 1-methyl-4-[[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]piperazine (440652-32-4)

Guidance literature:

Reference yield: 59.0%

2-Acetyl-5-bromothiophene (5370-25-2) + 1-methyl-4-[[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]piperazine (440652-32-4) → 1-[5-[2-[(4-methylpiperazin-1-yl)methyl]phenyl]-2-thienyl]ethan-1-one

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 4h; Inert atmosphere;

upstream raw materials:

1-methyl-piperazine

benzyl bromide

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