3-Benzoyl-2-nitrophenyl acetic acid

Base Information

• Chemical Name: 3-Benzoyl-2-nitrophenyl acetic acid
• CAS No.: 78940-53-1
• Molecular Formula: C15H11NO5
• Molecular Weight: 285.25
• Mol file: 78940-53-1.mol

Synonyms:3-Benzoyl-2-nitrophenyl acetic acid

Chemical Property of 3-Benzoyl-2-nitrophenyl acetic acid

Chemical Property:

• PSA: 100.19000
• LogP: 2.97610

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Benzoyl-2-nitrophenyl acetic acid

There total 4 articles about 3-Benzoyl-2-nitrophenyl acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-(3-benzoyl-2-nitrophenyl)propanedioic acid, diethyl ester (78940-50-8) → 3-benzoyl-2-nitrobenzeneacetic acid (78940-53-1)

Guidance literature:

With sulfuric acid; acetic acid; Heating;

DOI:10.1021/jm00170a039

Reference yield:

2-(3-benzoyl-2-nitrophenyl)propanedioic acid → 3-benzoyl-2-nitrobenzeneacetic acid (78940-53-1)

Guidance literature:

With potassium hydrogencarbonate; acetic acid; In sulfuric acid;

Reference yield:

[2-amino-3-chlorophenyl]phenylmethanone (5621-66-9) → 3-benzoyl-2-nitrobenzeneacetic acid (78940-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 59 percent / 90percent H₂O₂, trifluoroacetic anhydride / CH₂Cl₂ / 1 h / Heating

2: 46 percent / NaH / dimethylsulfoxide / 1 h / 100 °C

3: 48 percent / 20percent H₂SO₄, glacial CH₃CO₂H / Heating

With sulfuric acid; dihydrogen peroxide; sodium hydride; acetic acid; trifluoroacetic anhydride; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm00170a039

upstream raw materials:

2-(3-benzoyl-2-nitrophenyl)propanedioic acid, diethyl ester

[2-amino-3-chlorophenyl]phenylmethanone

(3-chloro-2-nitrophenyl)(phenyl)methanone

Refernces

• 1、 -. "3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters". . . Retrieved 2008/06/13.