5621-66-9

Usage

Main properties

1. Chemical formula: C13H10ClNO
2. Appearance: White to off-white solid
3. Melting point: 77-79°C

Specific content

1. Also known as: 2-Amino-3-chlorodiphenyl ketone
2. Member of the benzophenone family
3. Used as a building block in the synthesis of pharmaceuticals and organic compounds
4. Used as an intermediate in the production of UV absorbers, antioxidants, and photoinitiators for plastics and coatings
5. Potential applications in the medical and agricultural industries as a precursor in the synthesis of biologically active compounds and agrochemicals
6. Should be handled and used with caution due to potential health and environmental hazards.

Upstream product

• 53312-77-9 2-amino-3-chlorobenzonitrile 
• 100-58-3 phenylmagnesium bromide 
• 78940-48-4 (3-chloro-2-nitrophenyl)(phenyl)methanone 
• 5627-74-7 8-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one 
• 70777-07-0 7-chloro-2,3-diphenyl-1H-indole 
• 100-47-0 benzonitrile 
• 95-51-2 o-chloroaniline 
• 5176-14-7 3-phenyl-2,1-benzoxazole 
• 860686-09-5 benzoic acid-(2-benzoyl-6-chloro-anilide) 
• 4771-47-5 3-chloro-2-nitro-benzoic acid 
• 858231-16-0 1-acetyl-7-chloro-2,3-diphenyl-indole 

Downstream Products

• 78940-48-4 (3-chloro-2-nitrophenyl)(phenyl)methanone 
• 5571-46-0 9-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one 
• 78940-50-8 2-(3-benzoyl-2-nitrophenyl)propanedioic acid, diethyl ester 
• 78940-53-1 3-benzoyl-2-nitrobenzeneacetic acid 

Relevant academic research and scientific papers

Silver-Catalyzed Isocyanide Insertion into N?H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives

A silver-catalyzed [5+1] annulation of o-acylaryl isocyanides with ammonium acetate and hydroxlamine was developed for the efficient and practical synthesis of quinazolines and quinazoline 3-oxides in good to excellent yields, respectively. The domino process involved an unprecedented isocyanide insertion into the N?H bond of ammonia or hydroxylamine and followed by condensation reaction at ambient conditions. (Figure presented.).

ALKYL, FLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS

Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein: R1 is CH2CH2CF3; R2 is CH2(cyclopropyl), CH(CH3)(cyclopropyl), or CH2CH2CH3/

FLUOROALKYL AND FLUOROCYCLOALKYL 1,4-BENZODIAZEPINONE COMPOUNDS AS NOTCH|INHIBITORS

Disclosed are compounds of Formula (I): (Formula (I)) wherein: R1 is -CH2CH2CF3; R2 is -CH2CH2CH2F, -CH2CF2CH3, -CH2CH

BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS

The present invention is directed to compounds of Formula I: I (where variables R1, R2, R3, R6, R7, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: A novel series of 5-HT2A/2C receptor antagonists. Part 2

Following the programme started at Janssen Research Foundation searching for 5-HT2A/2C antagonists, we now report on the synthesis of a series of substituted 2-(Dimethylaminomethyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a] azepine derivatives. The 5-HT2A, 5-HT2C and H1 receptor affinities as well as the mCPP antagonistic activity of the compounds synthesised is described.

3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters

3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters are disclosed having the formula: STR1 wherein R1 is hydrogen or lower alkyl; R2 is OH, OM, O-lower alkyl, NH2, NH-lower alkyl or N,N-dilower alkyl; X is