6-benzyl-2-(trifluoroMethyl)-5,6,7,8- tetrahydro-1,6-naphthyridine

Base Information

• Chemical Name: 6-benzyl-2-(trifluoroMethyl)-5,6,7,8- tetrahydro-1,6-naphthyridine
• CAS No.: 1108192-98-8
• Molecular Formula: C16H15F3N2
• Molecular Weight: 292.304
• Hs Code.: 2933990090
• Mol file: 1108192-98-8.mol

Synonyms:6-benzyl-2-(trifluoroMethyl)-5,6,7,8- tetrahydro-1,6-naphthyridine

Chemical Property of 6-benzyl-2-(trifluoroMethyl)-5,6,7,8- tetrahydro-1,6-naphthyridine

Chemical Property:

• PSA: 16.13000
• LogP: 3.59660
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-benzyl-2-(trifluoroMethyl)-5,6,7,8- tetrahydro-1,6-naphthyridine

There total 5 articles about 6-benzyl-2-(trifluoroMethyl)-5,6,7,8- tetrahydro-1,6-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

1-phenylmethyl-4-piperidone (3612-20-2) + (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (59938-06-6) → 6-benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine (1108192-98-8)

Guidance literature:

1-phenylmethyl-4-piperidone; With pyrrolidine; In toluene; at 140 ℃; for 2h; Dean-Stark;

(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

With ammonium acetate; In 1,4-dioxane; at 150 ℃; for 108h; Reflux; Inert atmosphere; Microwave irradiation;

Reference yield:

(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (59938-06-6) + 1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine (16675-58-4) → 6-benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine (1108192-98-8)

Guidance literature:

(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one; 1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine; In 1,4-dioxane; at 20 ℃;

With ammonium acetate; for 3h; Reflux;

Reference yield:

4-ethoxy-1,1,1-trifluoro-3-butene-2-one (59938-06-6,17129-06-5) + 1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine (16675-58-4) → 6-benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine (1108192-98-8)

Guidance literature:

4-ethoxy-1,1,1-trifluoro-3-butene-2-one; 1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine; In 1,4-dioxane; at 20 ℃;

With ammonium acetate; In 1,4-dioxane; for 18h; Heating / reflux;

upstream raw materials:

4-ethoxy-1,1,1-trifluoro-3-butene-2-one

1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine

1-phenylmethyl-4-piperidone

(E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

Downstream raw materials:

2-trifluoromethyl-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

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