2-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

Base Information

• Chemical Name: 2-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
• CAS No.: 741736-98-1
• Molecular Formula: C9H10ClF3N2
• Molecular Weight: 238.64
• Hs Code.: 2933990090
• Mol file: 741736-98-1.mol

Synonyms:2-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

Chemical Property of 2-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

Chemical Property:

• PSA: 24.92000
• LogP: 2.87690
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride

There total 1 articles about 2-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine (1108192-98-8) → 2-trifluoromethyl-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (741736-98-1)

Guidance literature:

With 2-chloropropionyl chloride; In dichloromethane; at 40 ℃; for 18h;

Reference yield:

N-(4-bromo-2,6-dimethylphenyl)-3,3-dimethylbutanamide (1009344-67-5) + 2-trifluoromethyl-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (741736-98-1) → N-[2,6-dimethyl-4-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-phenyl]-3,3-dimethyl-butyramide (1108192-85-3)

Guidance literature:

With potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; DavePhos; In toluene; at 80 ℃;

upstream raw materials:

6-benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Downstream raw materials:

N-[2,6-dimethyl-4-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-phenyl]-3,3-dimethyl-butyramide

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