2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

Base Information

• Chemical Name: 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
• CAS No.: 1235318-89-4
• Molecular Formula: C₁₂H₁₂N₆S
• Molecular Weight: 272.333
• Mol file: 1235318-89-4.mol

Synonyms:2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-;5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine;4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-2-Pyrimidinamine;ADX88178

Chemical Property of 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

Chemical Property:

• PSA: 107.62000
• LogP: 2.75660

Purity/Quality:

97% ^*data from raw suppliers

ADX-88178 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-

There total 3 articles about 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

C20H20N6OS → ADX88178 (1235318-89-4)

Guidance literature:

With trifluoroacetic acid; at 90 ℃; for 3h;

DOI:10.1016/j.bmcl.2015.12.008

Reference yield:

4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-methylthiazol-2-amine (1235313-79-7) + 2-bromo-4-methyl-pyrimidine (130645-48-6) → ADX88178 (1235318-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 100 °C

2: trifluoroacetic acid / 3 h / 90 °C

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2015.12.008

Reference yield:

→ ADX88178 (1235318-89-4)

Guidance literature:

upstream raw materials:

4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-methylthiazol-2-amine

2-bromo-4-methyl-pyrimidine