130645-48-6

Usage

Uses

2-Bromo-4-methylpyrimidine is used as pharmaceutical intermediate.

InChI:InChI=1/C5H5BrN2/c1-4-2-3-7-5(6)8-4/h2-3H,1H3

Upstream product

• 13036-57-2 2-chloro-4-methylpyrimidine 
• 15231-48-8 2-hydroxy-4-methylpyrimidine 
• 108-52-1 4-Methyl-pyrimidin-2-ylamin 

Downstream Products

• 482630-16-0 4-methyl-2-(3,4,5-Trimethoxyphenyl)-pyrimidine 
• 1235318-89-4 ADX88178 
• 1355336-22-9 1-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(4-methylpyrimidin-2-ylamino)thiazol-5-yl)ethanone 
• 142790-12-3 2-(6-phenylethynyl-2-pyridinyl)-4-methylpyrimidine 

Relevant academic research and scientific papers

Cyclic diamine compound with 6-membered ring groups

A cyclic diamine compound of formula (1): wherein A is a single bond or C≡C; X and Y are individually CH or a nitrogen atom; m is 1 or 2; and n is a number of 1 to 5; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.

The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2- pyridyl)pyrimidines in the presence of tetrakis(triphenylphosphine)palladium(0) to produce a series of substituted pyridylpyrimidine fungicides in 32-99% yields. (C) 2000 Elsevier Science Ltd.

Spectrofluorometric method and compounds that are of value for the method

A chelate formed between Eu3+, Tb3+, Dy3+ and Sm3+ and a compound having the formula STR1 where A1-6 are single carbon or nitrogen atoms; n=1 or 2; R1-6 is nothing when A is a nitrogen, and hydrogen or an organic group when A is a carbon; Z and Z' are selected among --N(CH2 CH2 COO-)2, --N(CH2 COO-)2, --N(CH2 OPO32-)2 and --N(CH2 PO32-)2 ;--species that --X--Y is a substituent replacing a hydrogen anywhere in the parent compound; and --X--Y represents an organic group containing no chelating heteroatom closer than four atoms from a chelating heteroatom in the parent compound and X is a stable bridge containing certain groups and Y is selected from (a) specified relative groups allowing coupling to other compounds and (b) residues of compounds participating in biospecific affinity reactions.

New Heteroaromatic Complexing Agents and Luminescence of Their Europium(III) and Terbium(III) Chelates

Twelve heteroaromatic complexing agents 9a-l were synthesized with the purpose to develop suitable labels for time-resolved luminescence-based bioaffinity assays.The relative luminescence yields, excitation maxima, and emission decay constants of their europium(III) and terbium(III) chelates were determined.According to these results, 2,2',2'',2'''-tetrakis(acetic acid) (9e) and 2,2',2'',2'''-tetrakis(acetic acid) (9l) are the most promising agents.