130645-48-6

Basic information

• Product Name: 2-Bromo-4-methylpyrimidine
• Synonyms: 2-BROMO-4-METHYLPYRIMIDINE
• CAS NO: 130645-48-6
• Molecular Formula: C₅H₅BrN₂
• Molecular Weight: 173.01
• EINECS: 200-589-5
• Product Categories: Pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 130645-48-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 45-50℃
• Boiling Point: 264.96 °C at 760 mmHg
• Flash Point: 114.044 °C
• Appearance: Yellow power
• Density: 1.597 g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -1.06±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Bromo-4-methylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-methylpyrimidine(130645-48-6)
• EPA Substance Registry System: 2-Bromo-4-methylpyrimidine(130645-48-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 130645-48-6(Hazardous Substances Data)

Usage

Uses

2-Bromo-4-methylpyrimidine is used as pharmaceutical intermediate.

InChI:InChI=1/C5H5BrN2/c1-4-2-3-7-5(6)8-4/h2-3H,1H3

Upstream product

• 13036-57-2 2-chloro-4-methylpyrimidine 
• 15231-48-8 2-hydroxy-4-methylpyrimidine 
• 108-52-1 4-Methyl-pyrimidin-2-ylamin 

Downstream Products

• 1235318-89-4 ADX88178 
• 1355336-22-9 1-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-2-(4-methylpyrimidin-2-ylamino)thiazol-5-yl)ethanone 
• 482630-16-0 4-methyl-2-(3,4,5-Trimethoxyphenyl)-pyrimidine 
• 142790-12-3 2-(6-phenylethynyl-2-pyridinyl)-4-methylpyrimidine 

Relevant articles and documents

Cyclic diamine compound with 6-membered ring groups

A cyclic diamine compound of formula (1): wherein A is a single bond or C≡C; X and Y are individually CH or a nitrogen atom; m is 1 or 2; and n is a number of 1 to 5; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.

Spectrofluorometric method and compounds that are of value for the method

A chelate formed between Eu3+, Tb3+, Dy3+ and Sm3+ and a compound having the formula STR1 where A1-6 are single carbon or nitrogen atoms; n=1 or 2; R1-6 is nothing when A is a nitrogen, and hydrogen or an organic group when A is a carbon; Z and Z' are selected among --N(CH2 CH2 COO-)2, --N(CH2 COO-)2, --N(CH2 OPO32-)2 and --N(CH2 PO32-)2 ;--species that --X--Y is a substituent replacing a hydrogen anywhere in the parent compound; and --X--Y represents an organic group containing no chelating heteroatom closer than four atoms from a chelating heteroatom in the parent compound and X is a stable bridge containing certain groups and Y is selected from (a) specified relative groups allowing coupling to other compounds and (b) residues of compounds participating in biospecific affinity reactions.