5-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

Base Information

• Chemical Name: 5-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
• CAS No.: 30389-37-8
• Molecular Formula: C10H14ClNO
• Molecular Weight: 163.219
• Hs Code.: 2933499090
• Mol file: 30389-37-8.mol

Synonyms:5-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE;5-Methoxy-1,2,3,4-Tetrahydro-QinolineHydrochloride;5-methoxy-1,2,3,4-tetrahydroquinoline

Chemical Property of 5-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

Chemical Property:

• PSA: 21.26000
• LogP: 2.99330

Purity/Quality:

98%min ^*data from raw suppliers

5-methoxy-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

There total 1 articles about 5-METHOXY-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxyquinoline (6931-19-7) → 5-methoxy-1,2,3,4-tetrahydroquinoline (30389-37-8) + 5,6,7,8-tetrahydroquinoline (10500-57-9) + (+)-5-methoxy-5,6,7,8-tetrahydroquinoline + (-)-5-methoxy-5,6,7,8-tetrahydroquinoline

Guidance literature:

With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); (S,S)-(R,R)-PhTRAP; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In isopropyl alcohol; at 80 ℃; for 24h; under 37503.8 Torr; enantioselective reaction; Autoclave;

DOI:10.1039/c5cc01971k

Reference yield: 89.0%

5-methoxy-1,2,3,4-tetrahydroquinoline (30389-37-8) → 5-methoxyquinoline (6931-19-7)

Guidance literature:

With potassium tert-butylate; In o-xylene; at 140 ℃; for 36h; Inert atmosphere;

DOI:10.1002/adsc.201900499

Reference yield: 75.0%

5-methoxy-1,2,3,4-tetrahydroquinoline (30389-37-8) + 2-phenyl-1,8-naphthyridine-3-carbonitrile (15935-92-9) → 7-(5-methoxy-1,2,3,4-tetrahydroquinolin-8-yl)-2-phenyl-5,6,7,8-tetrahydro-1,8-naphthyridine-3-carbonitrile

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; In tert-Amyl alcohol; at 130 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201707702

upstream raw materials:

5-methoxyquinoline

Downstream raw materials:

5-hydroxy-1,2,3,4-tetrahydroquinoline

tert-butyl 5-hydroxy-3,4-dihydroquinoline-1(2H)-carboxylate

5-methoxyquinoline

Refernces