15935-92-9Relevant academic research and scientific papers
Direct Access to Nitrogen Bi-heteroarenes via Iridium-Catalyzed Hydrogen-Evolution Cross-Coupling Reaction
Chen, Chunlian,Chen, Xiuwen,Zhao, He,Jiang, Huanfeng,Zhang, Min
, p. 3390 - 3393 (2017)
Through cooperative actions of iridium catalyst and NaOTf additive we report a new direct access to nitrogen bi-heteroarenes via hydrogen-evolution cross-coupling of the β-site of indoles/pyrrole with the α-site of N-heteroarenes. The reaction proceeds in an atom- and redox-economic fashion together with the merits of an easily available catalyst system, broad substrate scope, excellent functional tolerance, and no need for external oxidants, offering a practical way to create π-conjugated systems.
Transition metal-free α-methylation of 1,8-naphthyridine derivatives using DMSO as methylation reagent
Jiang, Shaohua,Yang, Zhihai,Guo, Ziyin,Li, Yibiao,Chen, Lu,Zhu, Zhongzhi,Chen, Xiuwen
, p. 7416 - 7424 (2019/08/15)
A practical approach to the direct α-methylation of 1,8-naphthyridines under mild reaction conditions has been developed using simple and readily available DMSO as a convenient and environmentally friendly carbon source. This method is transition metal-free and highly chemoselective, shows good functional group tolerance, and uses DMSO as a methyl source, providing efficient and rapid access to an important compound class, 2-methyl-1,8-naphthyridines.
A flexible synthesis of naphthyridine derivatives through diazotization, triflation, and Suzuki reaction
Shireen Mohammed, Maher Khalid
, p. 21 - 25 (2021/06/12)
A facile and suitable method for the synthesis of different 1,8-Naphthyridine derivatives is depicted. The procedure is based on the diazotization and triflation reactions of commercially available 1,8-naphthyridine-2-amines followed by cross-coupling with aromatic and heteroaromatic boronic acids through Suzuki reaction. These processes reserved the required yields in high percentage. All synthesized compounds were identified by spectral data.
Tetrahydronaphthyridine-tetrahydroquiazoline derivative and synthetic method and application thereof
-
Paragraph 0025; 0038; 0039, (2017/10/13)
The invention belongs to the technical field of organic synthesis, and particularly relates to a tetrahydronaphthyridine-tetrahydroquiazoline derivative and a synthetic method and application thereof. The molecular formula of the tetrahydronaphthyridine-t
Hydrogen-Transfer-Mediated α-Functionalization of 1,8-Naphthyridines by a Strategy Overcoming the Over-Hydrogenation Barrier
Chen, Xiu-Wen,Zhao, He,Chen, Chun-Lian,Jiang, Huan-Feng,Zhang, Min
supporting information, p. 14232 - 14236 (2017/10/31)
A general catalytic hydrogen transfer-mediated α-functionalization of 1,8-naphthyridines is reported for the first time that benefits from a hydrogen transfer-mediated activation mode for non-activated pyridyl cores. The pyridyl α-site selectively couples with the C8-site of various tetrahydroquinolines (THQs) to afford novel α-functionalized tetrahydro 1,8-naphthyridines, a class of synthetically useful building blocks and potential candidates for the discovery of therapeutic and bio-active products. The utilization of THQs as inactive hydrogen donors (HDs) appears to be a key strategy to overcome the over-hydrogenation barrier and address the chemoselectivity issue. The developed chemistry features operational simplicity, readily available catalyst and good functional group tolerance, and offers a significant basis for further development of new protocols to directly transform or functionalize inert N-heterocycles.
