5-Amino-2-hydroxy-3-methylbenzoic acid

Base Information

• Chemical Name: 5-Amino-2-hydroxy-3-methylbenzoic acid
• CAS No.: 6265-14-1
• Molecular Formula: C8H9NO3
• Molecular Weight: 167.164
• Hs Code.: 2922509090
• DSSTox Substance ID: DTXSID00360176
• Nikkaji Number: J8.373I
• Wikidata: Q82141783
• Mol file: 6265-14-1.mol

Synonyms:5-amino-2-hydroxy-3-methylbenzoic acid;6265-14-1;5-Amino-2-hydroxy-3-methyl-benzoic acid;Benzoic acid, 5-amino-2-hydroxy-3-methyl-;5-Amino-2,3-cresotic acid;SCHEMBL2227236;2,3-Cresotic acid, 5-amino-;DTXSID00360176;HMS1685A10;BBL018961;MFCD04035023;STL119728;AKOS000111663;VS-06843;BB 0243999;CS-0312826;AE-641/00781015

Chemical Property of 5-Amino-2-hydroxy-3-methylbenzoic acid

Chemical Property:

• Melting Point: 271-272 °C
• Boiling Point: 390.6±42.0 °C(Predicted)
• PKA: 1.88±0.14(Predicted)
• PSA: 83.55000
• Density: 1.405±0.06 g/cm3(Predicted)
• LogP: 1.56220
• XLogP3: 2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 167.058243149
• Heavy Atom Count: 12
• Complexity: 183

Purity/Quality:

98%min ^*data from raw suppliers

5-amino-2-hydroxy-3-methylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1O)C(=O)O)N

Technology Process of 5-Amino-2-hydroxy-3-methylbenzoic acid

There total 8 articles about 5-Amino-2-hydroxy-3-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Aminosalicylic Acid (89-57-6) → 5-amino-2-hydroxy-3-methyl-benzoic acid (6265-14-1)

Guidance literature:

With sulfuric acid; In methanol;

Reference yield:

2-hydroxy-3-methyl-5-phenylazo-benzoic acid → 5-amino-2-hydroxy-3-methyl-benzoic acid (6265-14-1) + 5-amino-3-methyl-2-sulfooxy-benzoic acid

Guidance literature:

With ammonium sulfite; ammonia; at 90 - 93 ℃; Behandeln des Reaktionsgemisches mit Mineralsaeure;

Reference yield:

2-hydroxy-3-methyl-5-phenylazo-benzoic acid + ammonium hydroxide → 5-amino-2-hydroxy-3-methyl-benzoic acid (6265-14-1) + aniline (62-53-3)

Guidance literature:

at 90 ℃; beim Behandeln des Reaktionsgemisches mit ueberschuessiger Mineralsaeure;

upstream raw materials:

phenylhydrazine

3-methylsalicylic acid

5-Aminosalicylic Acid

Downstream raw materials:

acetic acid-(4-hydroxy-3-methyl-5-nitro-anilide)

3-Nitro-5-amino-2-oxy-1-methyl-benzol

4-amino-2-methylphenol

3-diazo-5-methyl-6-oxo-1,4-cyclohexadiene-1-carboxylic acid

Refernces