Nonaethylene glycol Monobenzyl ether

Base Information

• Chemical Name: Nonaethylene glycol Monobenzyl ether
• CAS No.: 868594-48-3
• Molecular Formula: C25H44O10
• Molecular Weight: 504.618
• Mol file: 868594-48-3.mol

Synonyms:BnO-PEG9-OH;Nonaethylene glycol Monobenzyl ether;1-Phenyl-2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-ol;Benzyl-PEG10-alcohol

Chemical Property of Nonaethylene glycol Monobenzyl ether

Chemical Property:

• PSA: 103.30000
• LogP: 1.32830
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

Nonaethyleneglycolmonobenzylether min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Nonaethylene glycol Monobenzyl ether

There total 21 articles about Nonaethylene glycol Monobenzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

1-(triphenylmethyloxy)-26-(phenylmethyloxy)-3,6,9,12,15,18,21,24-octaoxahexaeicosane (868594-47-2) → 26-(phenylmethyloxy)-3,6,9,12,15,18,21,24-octaoxahexaeicosan-1-ol (868594-48-3)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200701188

Reference yield: 95.0%

2-{2-[2-(2-{2-[2-(2-{2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-tetrahydro-pyran (669556-53-0) → 26-(phenylmethyloxy)-3,6,9,12,15,18,21,24-octaoxahexaeicosan-1-ol (868594-48-3)

Guidance literature:

DOI:10.1021/jo035042v

Reference yield: 88.0%

1-{2-[2-(2-{2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxymethyl}-4-methoxy-benzene (669556-59-6) → 26-(phenylmethyloxy)-3,6,9,12,15,18,21,24-octaoxahexaeicosan-1-ol (868594-48-3)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; acetonitrile; at 0 - 20 ℃; for 4h;

DOI:10.1021/jo035042v

upstream raw materials:

1-(triphenylmethyloxy)-26-(phenylmethyloxy)-3,6,9,12,15,18,21,24-octaoxahexaeicosane

2-{2-[2-(2-{2-[2-(2-{2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-tetrahydro-pyran

1-{2-[2-(2-{2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxymethyl}-4-methoxy-benzene

17-(2H-tetrahydropyran-2'-yloxy)-3,6,9,12,15-pentaoxaheptadecan-1-ol

Downstream raw materials:

toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-{2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester

Refernces

• 1、 Pilkington-Miksa, Michael A.,Sarkar, Supti,Writer, Michele J.,Barker, Susie E.,Shamlou, Parviz Ayazi,Hart, Stephen L.,Hailes, Helen C.,Tabor, Alethea B.. "Synthesis of bifunctional integrin-binding peptides containing PEG spacers of defined length for non-viral gene delivery". experimental part. p. 2900 - 2914. Retrieved 2009/04/11.
• 2、 Gartiser, Thierry,Selve, Claude,Mansuy, Laurence,Robert, Alain,Delpuech, Jean-Jacques. "CHIMIE DES OLIGOETHYLENE-GLYCOLS: SYNTHESE DE TENSIO-ACTIFS NON IONIQUES POLYFLUORES MONODISPERSES". . p. 2672 - 2691. Retrieved 2007/10/02.