diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Base Information

Chemical Name:diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate
CAS No.:1035260-90-2
Molecular Formula:C19H23ClO6
Molecular Weight:382.84
Hs Code.:
Mol file:1035260-90-2.mol

Synonyms:diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Suppliers and Price of diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Chemical Property:

PSA：78.90000
LogP:2.69970

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

There total 4 articles about diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3648-75-7
4-(4-Chloro-phenyl)-tetrahydro-pyran-4-carbonyl chloride

: 105-53-3
diethyl malonate

: 1035260-90-2
diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: diethyl malonate; With triethylamine; magnesium chloride; In Isopropyl acetate; at 20 ℃; for 2.5h;

4-(4-Chloro-phenyl)-tetrahydro-pyran-4-carbonyl chloride; In Isopropyl acetate; at 5 - 20 ℃; for 2h;

Reference yield:

: 3648-57-5
4-(4-chlorophenyl)tetrahydro-2H-pyran-4-carboxylic acid

: 1035260-90-2
diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / Isopropyl acetate / 2.33 h / 20 °C

2.1: triethylamine; magnesium chloride / Isopropyl acetate / 2.5 h / 20 °C

2.2: 2 h / 5 - 20 °C

With oxalyl dichloride; triethylamine; magnesium chloride; N,N-dimethyl-formamide; In Isopropyl acetate;

Reference yield:

: 3648-74-6
4-(4-chlorophenyl)tetrahydro-2H-pyran-4-carbonitrile

: 1035260-90-2
diethyl 2-(4-(4-chlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; water / 1,4-dioxane / 48 h / 100 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / Isopropyl acetate / 2.33 h / 20 °C

3.1: triethylamine; magnesium chloride / Isopropyl acetate / 2.5 h / 20 °C

3.2: 2 h / 5 - 20 °C

With oxalyl dichloride; sulfuric acid; water; triethylamine; magnesium chloride; N,N-dimethyl-formamide; In 1,4-dioxane; Isopropyl acetate;