(S)-(+)-2-AMINO-1-PHENYLETHANOL HYDROCHLORIDE

Base Information

• Chemical Name: (S)-(+)-2-AMINO-1-PHENYLETHANOL HYDROCHLORIDE
• CAS No.: 71025-82-6
• Molecular Formula: C8H12ClNO
• Molecular Weight: 0
• Hs Code.: 2922199090
• Mol file: 71025-82-6.mol

Synonyms:(S)-(+)-2-AMINO-1-PHENYLETHANOL HYDROCHLORIDE

Chemical Property of (S)-(+)-2-AMINO-1-PHENYLETHANOL HYDROCHLORIDE

Chemical Property:

• Melting Point: 165-166 °C
• PSA: 46.25000
• LogP: 2.18100

Purity/Quality:

(S)-2-Amino-1-phenylethanolhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-(+)-2-AMINO-1-PHENYLETHANOL HYDROCHLORIDE

There total 2 articles about (S)-(+)-2-AMINO-1-PHENYLETHANOL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminoacetophenone hydrochloride (5468-37-1) → (S)-2-amino-1-phenyl-ethanol; hydrochloride (71025-82-6) + (R)-2-amino-1-phenyl-ethanol; hydrochloride (18867-43-1)

Guidance literature:

With hydrogen; Rh(I)-complex of (R)-Cy-BIMOP; In methanol; at 50 ℃; for 168h; under 68400.1 Torr; Mechanism; Others Rh(I)-complex of unsymmetrical chiral bisphosphines, var. pressure, temp. and time, also itaconic acid.;

DOI:10.1016/S0957-4166(00)82304-6

Reference yield:

2-aminoacetophenone hydrochloride (5468-37-1) → (S)-2-amino-1-phenyl-ethanol; hydrochloride (71025-82-6)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; N-(tert-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine; hydrogen; triethylamine; In methanol; at 20 ℃; for 20h; under 3800 Torr; Yield given;

DOI:10.1248/cpb.40.2921

upstream raw materials:

2-aminoacetophenone hydrochloride

Refernces

• 1、 Devocelle, Marc,Agbossou, Francine,Mortreux, André. "Asymmetric Hydrogenation of α, β, and γ-Aminoketones Catalyzed by Cationic Rhodium(I){AMPP} Complexes". . p. 1306 - 1308. Retrieved 2007/10/03.
• 2、 Inoguchi,Fujie,Yoshikawa,Achiwa. "Development of new 6-membered chelating chiral bisphosphine ligands for rhodium-catalyzed asymmetric hydrogenation". . p. 2921 - 2926. Retrieved 2007/10/02.