N,N-Dimethyl-L-Alanine

Base Information

• Chemical Name: N,N-Dimethyl-L-Alanine
• CAS No.: 157431-09-9
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• Mol file: 157431-09-9.mol

Synonyms:N,N-Dimethyl-L-Alanine;N,N-Dimethyl-L-Ala-OH;(S)-2-(DiMethylaMino)propanoic acid;(R)-2-(dimethylamino)propanoic acid

Chemical Property of N,N-Dimethyl-L-Alanine

Chemical Property:

• Melting Point: 184℃
• Boiling Point: 179.9±23.0℃ (760 Torr)
• Flash Point: 62.6±22.6℃
• PSA: 40.54000
• Density: 1.033±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 0.02110
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-2-(Dimethylamino)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Dimethyl-L-Alanine

There total 4 articles about N,N-Dimethyl-L-Alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + D-Alanine (338-69-2,25191-17-7,18875-37-1) → Ν,Ν-dimethyl D-alanine (157431-09-9)

Guidance literature:

formaldehyd; D-Alanine; With sodium dihydrogenphosphate dihydrate; In water; at 20 ℃; for 1h; pH=5.25;

With zinc; In water; at 20 ℃; for 1h;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) → Ν,Ν-dimethyl D-alanine (157431-09-9)

Guidance literature:

With palladium on activated charcoal; water; Hydrogenation;

DOI:10.1039/jr9500001342

Reference yield:

D-Alanine (338-69-2,25191-17-7,18875-37-1) → Ν,Ν-dimethyl D-alanine (157431-09-9)

Guidance literature:

(methylation);

DOI:10.1111/j.2042-7158.1963.tb12798.x

upstream raw materials:

formaldehyd

D-Alanine

Downstream raw materials:

(R)-2-(dimethylamino)propane-1-ol

(R)-(-)-2,2-diphenyl-4-dimethylaminopentanenitrile

(R)-methadone hydrochloride

Refernces

• 1、 -. "SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF". Paragraph 00300-00302. . Retrieved 2017/03/14.
• 2、 -. "METABOTROPIC GLUTAMATE RECEPTORS 5 MODULATORS AND METHODS OF USE THEREOF". Page/Page column 121-122. . Retrieved 2012/12/13.