1-Chloro-3-hexadecyloxy-2-propanol

Base Information

• Chemical Name: 1-Chloro-3-hexadecyloxy-2-propanol
• CAS No.: 18371-73-8
• Molecular Formula: C19H39ClO2
• Molecular Weight: 334.97
• Hs Code.: 2909499000
• Mol file: 18371-73-8.mol

Synonyms:1-Chloro-3-hexadecyloxy-2-propanol

Chemical Property of 1-Chloro-3-hexadecyloxy-2-propanol

Chemical Property:

• PSA: 29.46000
• LogP: 6.08400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Chloro-3-hexadecyloxy-2-propanol

There total 5 articles about 1-Chloro-3-hexadecyloxy-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-Hexadecanol (36653-82-4,124-29-8) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-chloro-3-hexadecylhydroxy-2-propanol (18371-73-8)

Guidance literature:

With tin(IV) chloride; at 70 ℃; for 3h;

Reference yield: 96.0%

cetyl glycidyl ether (117606-92-5,121403-67-6,123483-78-3,15965-99-8) → 1-chloro-3-hexadecylhydroxy-2-propanol (18371-73-8)

Guidance literature:

With tetrabutyl-ammonium chloride; trifluoroacetic acid; In chloroform; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.01.083

Reference yield: 80.0%

cetyl glycidyl ether (117606-92-5,121403-67-6,123483-78-3,15965-99-8) + benzoic acid (65-85-0,8013-63-6) → 1-chloro-3-hexadecylhydroxy-2-propanol (18371-73-8) + C26H44O4

Guidance literature:

With cetyltrimethylammonium chloride; In toluene; at 100 ℃; for 20h;

DOI:10.1039/c9ra09217j

upstream raw materials:

1-Hexadecanol

epichlorohydrin

cetyl glycidyl ether

benzoic acid

Downstream raw materials:

3-(hexadecyloxy)-1,2-propanediol

2-benzyloxy-3-hexadecyloxy-1-propanol

1-O-hexadecyl-3-O-trityl-rac-glycerol

2-O-Benzyl-1-O-hexadecyl-3-O-trityl-glycerin

Refernces

• 1、 Nascimento, Thiana Santiago,Braga, Esther Faria,Casaes Gomes, Giselle Cristina,Batista, William Rom?o,Mazzei Albert, André Luís,Capella Lopes, Rosangela Sabbatini,Lopes, Claudio Cerqueira. "Synthesis of natural 1- O -alkylglycerols: A study on the chemoselective opening of the epoxide ring by onium quaternary salts (N and P) and ionic liquids". . p. 1050 - 1054. Retrieved 2020/01/23.
• 2、 Rattay, Bernd,Brezesinski, Gerald,Dobner, Bodo,Foerster, Guenter,Nuhn, Peter. "Influence of α-branched fatty acid chains on the thermotropic behaviour of racemic 1-O-hexadecyl-2-acyl-glycero-3-phosphocholines". . p. 81 - 92. Retrieved 2007/10/02.