Phosphorochloridic acid (R)-2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester

Base Information

• Chemical Name: Phosphorochloridic acid (R)-2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester
• CAS No.: 96924-84-4
• Molecular Formula: C₂₈H₄₉BrClO₅P
• Molecular Weight: 612.025
• Mol file: 96924-84-4.mol

Synonyms:

Chemical Property of Phosphorochloridic acid (R)-2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphorochloridic acid (R)-2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester

There total 16 articles about Phosphorochloridic acid (R)-2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoethylphosphoric acid dichloride (4167-02-6) + 2-benzyloxy-3-hexadecyloxy-1-propanol (18678-94-9) → Phosphorochloridic acid 2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester (96924-84-4)

Guidance literature:

With triethylamine; In Trichloroethylene; for 4h;

DOI:10.1016/S0040-4039(00)99049-X

Reference yield:

3-(hexadecyloxy)-1,2-propanediol (6145-69-3) → Phosphorochloridic acid 2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester (96924-84-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / pyridine / Ambient temperature

2: t-BuOK / 2-methyl-propan-2-ol / 70 °C

3: BF₃*MeOH / CH₂Cl₂ / Ambient temperature

4: NEt₃ / CHCl₃ / Ambient temperature

With pyridine; potassium tert-butylate; boron trifluoride methanol complex; triethylamine; In dichloromethane; chloroform; tert-butyl alcohol;

DOI:10.1016/0009-3084(94)02405-T

Reference yield:

1-Hexadecanol (36653-82-4,124-29-8) → Phosphorochloridic acid 2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester (96924-84-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / SnCl₄ / 70 °C

2: 98 percent / 40percent aq. NaOH / 80 - 90 °C

3: 59 percent / 0.4percent aq. H₂SO₄ / propan-2-ol / Heating

4: 68 percent / pyridine / Ambient temperature

5: t-BuOK / 2-methyl-propan-2-ol / 70 °C

6: BF₃*MeOH / CH₂Cl₂ / Ambient temperature

7: NEt₃ / CHCl₃ / Ambient temperature

With pyridine; sodium hydroxide; sulfuric acid; potassium tert-butylate; boron trifluoride methanol complex; tin(IV) chloride; triethylamine; In dichloromethane; chloroform; isopropyl alcohol; tert-butyl alcohol;

DOI:10.1016/0009-3084(94)02405-T

upstream raw materials:

2-bromoethylphosphoric acid dichloride

2-benzyloxy-3-hexadecyloxy-1-propanol

3-(hexadecyloxy)-1,2-propanediol

1-Hexadecanol

Downstream raw materials:

C₂₈H₄₉BrO₆P^(1-)*Na⁽¹⁺⁾

Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin

2-hydroxy-3-(hexadecyloxy)-propyl 2-trimethylammonioethyl phosphate

3-O-hexadecyl-2-acetyl-sn-glycero-1-phosphocholine