4-(TrifluoroMethyl)benzenebutanal

Base Information

• Chemical Name: 4-(TrifluoroMethyl)benzenebutanal
• CAS No.: 528867-43-8
• Molecular Formula: C₁₁H₁₁F₃O
• Molecular Weight: 216.203
• Mol file: 528867-43-8.mol

Synonyms:4-(TrifluoroMethyl)benzenebutanal;4-(4-TrifluoroMethylphenyl)butyraldehyde;4-[4-(TrifluoroMethyl)phenyl]butanal

Chemical Property of 4-(TrifluoroMethyl)benzenebutanal

Chemical Property:

• Boiling Point: 255.1±40.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.161±0.06 g/cm3(Predicted)
• LogP: 3.22700

Purity/Quality:

98%Min ^*data from raw suppliers

4-(Trifluoromethyl)benzenebutanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(TrifluoroMethyl)benzenebutanal is used for preparation of pyridinone and pyrimidinone compounds as Lp-PLA2 inhibitors for treating atherosclerosis.

Technology Process of 4-(TrifluoroMethyl)benzenebutanal

There total 10 articles about 4-(TrifluoroMethyl)benzenebutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

→ 4-(4-(trifluoromethyl)phenyl)butanal (528867-43-8)

Guidance literature:

With tetrafluoroboric acid diethyl ether complex; In chloroform; for 12h; Reflux;

With tetrabutyl ammonium fluoride; dihydrogen peroxide; potassium hydrogencarbonate; In methanol; at 20 ℃; for 2h;

Reference yield:

carbon monoxide (201230-82-2) + 1-allyl-4-(trifluoromethyl)benzene (1813-97-4) → p-Trifluoromethylphenyl-2-butyraldehyd (73853-88-0) + 4-(4-(trifluoromethyl)phenyl)butanal (528867-43-8) + C11H11F3O

Guidance literature:

With dicarbonyl(acetylacotonato)rhodium(I); hydrogen; ruphos; In toluene; at 80 ℃; for 10h; under 22502.3 Torr; Overall yield = 78 %Chromat.; regioselective reaction; Autoclave;

DOI:10.1002/aoc.4478

Reference yield:

4-[4-(trifluoromethyl)phenyl]butan-1-ol (528867-41-6) → 4-(4-(trifluoromethyl)phenyl)butanal (528867-43-8)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/cmdc.201600249

upstream raw materials:

4-(4-trifluoromethylphenyl)but-3-yn-1-ol

4-[4-(trifluoromethyl)phenyl]butan-1-ol

4-Iodobenzotrifluoride

3-(4-trifluoromethylphenyl)propionic acid