(S)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate

Base Information

• Chemical Name: (S)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate
• CAS No.: 1036027-87-8
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Hs Code.: 2933399990
• Mol file: 1036027-87-8.mol

Synonyms:tert-butyl 4-[(1S)-1-aminoethyl]piperidine-1-carboxylate;tert-butyl (S)-4-(1-aminoethyl)piperidine-1-carboxylate

Chemical Property of (S)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 310.3±15.0 °C(Predicted)
• PKA: 10.60±0.29(Predicted)
• PSA: 55.56000
• Density: 1.019±0.06 g/cm3(Predicted)
• LogP: 2.61890

Purity/Quality:

99%, ^*data from raw suppliers

(S)-1-Boc-4-(1-aminoethyl)piperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate

There total 4 articles about (S)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl 4-((S)-1-(((R)-tert-butylsulfinyl)amino)ethyl)piperidine-1-carboxylate → 4-((S)-1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (1036027-87-8)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 1h;

Reference yield:

C8H8O3*C12H24N2O2 (1036027-88-9) → 4-((S)-1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (1036027-87-8)

Guidance literature:

With sodium hydroxide; In dichloromethane;

Reference yield:

tert-butyl 4-[(E)-{[(R)-2-methylpropane-2-sulfinyl]imino}methyl]piperidine-1-carboxylate → 4-((S)-1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (1036027-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: hydrogenchloride / methanol; water / 1 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; methanol; water;

upstream raw materials:

C₈H₈O₃*C₁₂H₂₄N₂O₂

tert butyl 4-formylpiperidine-1-carboxylate

Downstream raw materials:

(S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

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