(S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate
CAS No.:1437716-26-1
Molecular Formula:C₂₁H₃₂ClN₃O₅
Molecular Weight:441.955
Hs Code.:

Synonyms:(S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

There total 4 articles about (S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1036027-87-8
4-((S)-1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1349744-81-5
1-chloro-4-methoxy-5-nitro-2-vinylbenzene

: 1437716-26-1
(S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

Guidance literature:: With quinoline; In isopropyl alcohol; for 56h; Reflux;

Reference yield:

: 1027833-17-5
1-bromo-2-chloro-5-fluoro-4-nitrobenzene

: 1437716-26-1
(S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 0 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / propan-1-ol / 4 h / Reflux

3: quinoline / isopropyl alcohol / 56 h / Reflux

With quinoline; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In propan-1-ol; isopropyl alcohol;

Reference yield:

: 201849-15-2
2-bromo-1-chloro-4-fluoro-benzene

: 1437716-26-1
(S)-tert-butyl 4-(1-(2-(2-chloro-5-methoxy-4-nitrophen)ethylamino)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium nitrate; sulfuric acid / -5 °C / Cooling with ice

2: 0 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / propan-1-ol / 4 h / Reflux

4: quinoline / isopropyl alcohol / 56 h / Reflux

With quinoline; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; potassium nitrate; triethylamine; In propan-1-ol; isopropyl alcohol;