1,5-Pentanediylbisphosphonic acid tetraethyl ester

Base Information

• Chemical Name: 1,5-Pentanediylbisphosphonic acid tetraethyl ester
• CAS No.: 21458-48-0
• Molecular Formula: C₁₃H₃₀O₆P₂
• Molecular Weight: 344.325
• Mol file: 21458-48-0.mol

Synonyms:1,5-Pentanediylbisphosphonic acid tetraethyl ester

Chemical Property of 1,5-Pentanediylbisphosphonic acid tetraethyl ester

Chemical Property:

• Vapor Pressure: 3.56E-07mmHg at 25°C
• Boiling Point: 429.3°C at 760 mmHg
• Flash Point: 226.8°C
• PSA: 90.68000
• Density: 1.086g/cm³
• LogP: 4.68890

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,5-Pentanediylbisphosphonic acid tetraethyl ester

There total 2 articles about 1,5-Pentanediylbisphosphonic acid tetraethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1,5-dibromo-pentane (111-24-0) + triethyl phosphite (122-52-1) → tetraethyl pentane-1,5-bisphosphonate (21458-48-0)

Guidance literature:

at 120 - 156 ℃; for 27h; Inert atmosphere;

DOI:10.1016/j.tet.2017.12.011

Reference yield:

→ tetraethyl pentane-1,5-bisphosphonate (21458-48-0)

Guidance literature:

DOI:10.1016/0022-1902(61)80447-8

Reference yield: 96.0%

tetraethyl pentane-1,5-bisphosphonate (21458-48-0) → pentane-1,5-bisphosphonic acid (4672-25-7)

Guidance literature:

With hydrogenchloride; for 10h; Heating;

DOI:10.1021/jm970839y

upstream raw materials:

1,5-dibromo-pentane

triethyl phosphite

Downstream raw materials:

pentane-1,5-bisphosphonic acid

Refernces

• 1、 Alder, Roger W.,Ganter, Christian,Gil, Michelle,Gleiter, Rolf,Harris, Christopher J.,et al.. "Medium-ring diphosphines from diphosphabicycloalkanes: stereoselective syntheses, structure and properties". . p. 1643 - 1656. Retrieved 2007/10/03.